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Gene Review

lpfC  -  long polar fimbrial outer membrane usher...

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

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Disease relevance of lpfC

  • Synergistic effect of mutations in invA and lpfC on the ability of Salmonella typhimurium to cause murine typhoid [1].

High impact information on lpfC

  • The defect of the lpfC mutant in adhesion to Peyer's patches could be complemented by introducing lpfABCDE on a cosmid [2].
  • Electron microscopic analysis of histological sections taken from Peyer's patches after intragastric infection of mice showed that, in contrast to the S. typhimurium wild type, the isogenic lpfC mutant did not destroy M cells of the follicle-associated epithelium [2].
  • When mice were infected with a mixture of the lpfC mutant and isogenic wild-type S. typhimurium, the lpfC mutant was recovered in lower numbers from Peyer's patches, mesenteric lymph nodes, liver, and spleen [2].
  • These data show that both the invA- and lpfC-mediated pathways of intestinal perforation are conserved in mouse virulent Salmonella serotypes [1].
  • An S. typhimurium lpfC mutant was unable to adhere to or to invade HEp-2 cells, while an S. typhimurium fim deletion mutant did not attach to or enter HeLa cells [3].

Analytical, diagnostic and therapeutic context of lpfC

  • In an organ culture model using murine intestinal loops, lpfC mutants were shown to be associated in lower numbers than wild-type bacteria with Peyer's patches but not with villous intestine [2].


  1. Synergistic effect of mutations in invA and lpfC on the ability of Salmonella typhimurium to cause murine typhoid. Bäumler, A.J., Tsolis, R.M., Valentine, P.J., Ficht, T.A., Heffron, F. Infect. Immun. (1997) [Pubmed]
  2. The lpf fimbrial operon mediates adhesion of Salmonella typhimurium to murine Peyer's patches. Bäumler, A.J., Tsolis, R.M., Heffron, F. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  3. Contribution of fimbrial operons to attachment to and invasion of epithelial cell lines by Salmonella typhimurium. Bäumler, A.J., Tsolis, R.M., Heffron, F. Infect. Immun. (1996) [Pubmed]
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