Disease relevance of Intestinal Perforation

• Two patients in the prednisolone group had serious complications (one had intestinal perforation and one an abdominal-wall fistula) [1].
• Ascitic fluid carcinoembryonic antigen and alkaline phosphatase levels for the differentiation of primary from secondary bacterial peritonitis with intestinal perforation [2].
• Spontaneous intestinal perforation after oral ibuprofen treatment of patent ductus arteriosus in two very-low-birthweight infants [3].
• Therefore, we believe that despite severe respiratory failure requiring ECMO and anticoagulation with heparin, infants with intestinal perforation can be managed surgically with anticipated survival and good long-term prognosis [4].
• CONCLUSION: A persistent metabolic acidosis, decreasing platelet, and increasing blood glucose level on several successive days might predict a developing NEC, and leukocyte values above 30 x 10(9)/L, pH less than 7.25, and a blood glucose rise by 1.5 mmol/L or more within 24 hours predict NEC with intestinal perforation [5].

High impact information on Intestinal Perforation

• Occult intestinal perforation complicated steroid therapy in one case [6].
• Spontaneous intestinal perforations in extremely premature infants are associated with glucocorticoid-induced thinning of the ileal bowel wall [7].
• The least variability (sevenfold) was for estimates of late, small intestinal perforation/obstruction after a one-third volume received 50 Gy with concurrent 5-fluorouracil (RE range 5-35%) [8].
• Intestinal perforation associated with octreotide therapy in scleroderma [9].
• Potential benefits of early dexamethasone therapy at the dosing schedule used in this trial need to be weighed against the risk for early intestinal perforation [10].

Chemical compound and disease context of Intestinal Perforation

• Intestinal perforation following enteral administration of indomethacin [11].
• Higher concentrations of the cationic agents BAC and benzethonium chloride caused a generalized tissue damage including disruption of the smooth muscle, lymphocytic infiltration, intestinal perforation and death [12].
• The patients who achieved a complete remission with medical treatment, who had no history of intestinal perforation, and who received azathioprine after operation showed better clinical courses [13].
• METHODS: Clinical and laboratory records of two preterm infants, who developed intestinal perforation after ibuprofen administration, were evaluated [3].
• Renal excretion of enteral gastrografin in the absence of free intestinal perforation [14].

Gene context of Intestinal Perforation

• Intestinal perforation in a patient with severe ankylosing spondylitis [15].
• With multivariate analysis age >1 year, serum CRP >200 mg/l and colon diameter >2.5 times of width of L1-VB, inadequate early hydration and delay in rectal tube insertion were the most significant factors associated with intestinal perforation [16].
• Two cases of intestinal perforation in patients on anti-rheumatic treatment with etanercept [17].
• Death was independently associated with seizures, intestinal perforation, pneumonia, and delirium or coma [18].

Analytical, diagnostic and therapeutic context of Intestinal Perforation

• CONCLUSION: Although ibuprofen is a reasonable treatment alternative to indomethacin, randomized controlled trials, which address potential adverse effects including spontaneous intestinal perforation, are needed [3].
• The matched pairs were similar in all respects except for a significantly higher percent increase in blood urea nitrogen level after treatment with indomethacin (Wilcoxon signed-rank test, p < 0.02) in infants with intestinal perforation [19].

References