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Gene Review:

dnaA - chromosomal replication initiation protein...

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Bagdasarian, M. et al., Blanc-Potard, A.B. et al., Hryniewicz, M. et al., Backhaus, H. et al., Engstrom, J. et al.

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Disease relevance of dnaA

Histidine operon deattenuation in dnaA mutants of Salmonella typhimurium correlates with a decrease in the gene dosage ratio between tRNA(His) and histidine biosynthetic loci [1].

High impact information on dnaA

The suppressor phenotype is also sensitive to modulation by the dnaA genotype [2].
Obviously the temperature sensitive function of the dnaA-product is dispensable for P22 DNA replication, especially for its initiation [3].
Additional evidence suggesting that the cryptic plasmid controls its own initiation of replication independently of the function of the chromosomal dnaA gene is supplied by the results of the determination of incorporation of labelled thymidine into CCC DNA of the dnaA1 strain at the nonpermissive temperature [4].
It is suggested that the cryptic plasmid may integrate into the chromosome of S. typhimurium and this integration may result in suppression of the dnaA mutation [4].
Suppression of dnaA mutation by F'lac and cryptic LT2 plasmid was used for selecting clones containing these plasmids integrated into rfa and galK genes [5].

References

Histidine operon deattenuation in dnaA mutants of Salmonella typhimurium correlates with a decrease in the gene dosage ratio between tRNA(His) and histidine biosynthetic loci. Blanc-Potard, A.B., Figueroa-Bossi, N., Bossi, L. J. Bacteriol. (1999) [Pubmed]
Interaction of DNA polymerase III gamma and beta subunits in vivo in Salmonella typhimurium. Engstrom, J., Wong, A., Maurer, R. Genetics (1986) [Pubmed]
Replication and maturation of phage P22 in a mutant of Salmonella typhimurium temperature sensitive in initiation of DNA replication. Backhaus, H., Schmieger, H. Mol. Gen. Genet. (1979) [Pubmed]
Integrative suppression of a dnaA mutation in Salmonella typhimurium. Bagdasarian, M., Hryniewicz, M., Zdzienicka, M. Mol. Gen. Genet. (1975) [Pubmed]
Integration of F factor and cryptic LT2 plasmid into a specific site of the Salmonella typhimurium chromosome. Hryniewicz, M., Bagdasarian, M., Bagdasarian, M. Acta Biochim. Pol. (1979) [Pubmed]

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