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Gene Review

dnaA  -  chromosomal replication initiation protein...

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

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Disease relevance of dnaA


High impact information on dnaA

  • The suppressor phenotype is also sensitive to modulation by the dnaA genotype [2].
  • Obviously the temperature sensitive function of the dnaA-product is dispensable for P22 DNA replication, especially for its initiation [3].
  • Additional evidence suggesting that the cryptic plasmid controls its own initiation of replication independently of the function of the chromosomal dnaA gene is supplied by the results of the determination of incorporation of labelled thymidine into CCC DNA of the dnaA1 strain at the nonpermissive temperature [4].
  • It is suggested that the cryptic plasmid may integrate into the chromosome of S. typhimurium and this integration may result in suppression of the dnaA mutation [4].
  • Suppression of dnaA mutation by F'lac and cryptic LT2 plasmid was used for selecting clones containing these plasmids integrated into rfa and galK genes [5].


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