Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

ilvG - acetolactate synthase 2 catalytic subunit

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Blazey, D.L. et al., LaRossa, R.A. et al., Shaw, K.J. et al., Wiersma, P.A. et al., Blazey, D.L. et al.

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Disease relevance of ilvG

Specific truncations of an acetolactate synthase gene from Brassica napus efficiently complement ilvB/ilvG mutants of Salmonella typhimurium [1].

Psychiatry related information on ilvG

The major control locus, designated ilvO, is located before ilvG forming an ilvOGEDA transcriptional unit that is multivalently repressed by isoleucine, valine and leucine [2].

High impact information on ilvG

One orientation of Tn10 insertions in ilvG and ilvE permits low-level expression of the downstream ilvEDA and ilvDA genes, respectively [3].
They have acetolactate synthase activity that is insensitive to sulfometuron methyl because of mutations in or near ilvG, the structural gene for acetolactate synthase isozyme II [4].
As a result, cells were starved for valine, and both ilvB (encoding acetohydroxy acid synthase I) and ilvGEDA (ilvG encodes acetohydroxy acid synthase II) were derepressed [5].
Examination of ilv enzyme levels confirms that the direction of transcription of ilvGEDA is from ilvG to ilvA [2].

References

Specific truncations of an acetolactate synthase gene from Brassica napus efficiently complement ilvB/ilvG mutants of Salmonella typhimurium. Wiersma, P.A., Hachey, J.E., Crosby, W.L., Moloney, M.M. Mol. Gen. Genet. (1990) [Pubmed]
Genetic organization of the Salmonella typhimurium ilv gene cluster. Blazey, D.L., Burns, R.O. Mol. Gen. Genet. (1979) [Pubmed]
Transcriptional activity of the transposable element Tn10 in the Salmonella typhimurium ilvGEDA operon. Blazey, D.L., Burns, R.O. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
The sulfonylurea herbicide sulfometuron methyl is an extremely potent and selective inhibitor of acetolactate synthase in Salmonella typhimurium. LaRossa, R.A., Schloss, J.V. J. Biol. Chem. (1984) [Pubmed]
Substrate channeling: alpha-ketobutyrate inhibition of acetohydroxy acid synthase in Salmonella typhimurium. Shaw, K.J., Berg, C.M. J. Bacteriol. (1980) [Pubmed]

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