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Gene Review:

traJ - regulatory protein

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Camacho, E.M. et al., Chu, C. et al., Meadow, N.D. et al.

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Disease relevance of traJ

Regulation of traJ transcription in the Salmonella virulence plasmid by strand-specific DNA adenine hemimethylation [1].
Effects of Mutations and Truncations on the Kinetic Behavior of IIAGlc, a Phosphocarrier and Regulatory Protein of the Phosphoenolpyruvate Phosphotransferase System of Escherichia coli [2].

High impact information on traJ

The traJ gene of the virulence plasmid of Salmonella enterica serovar Typhimurium (pSLT) encodes a transcriptional activator of the transfer operon [1].
The effect of GATC-II hemimethylation on Lrp binding is strand-specific: methylation of the traJ non-coding strand permits formation of the major Lrp-DNA retardation complex, but methylation of the coding strand does not [1].
The upstream-activating-sequence of the pSLT traJ promoter contains two Lrp binding sites (LRP-1 and LRP-2), both necessary for transcriptional activation [1].
Major nucleotide sequence variations were found in traJ, traY, and the Tra protein binding sites sby and sbm. sby of pSPV showed higher similarity than that of pSEV or pSTV to that of the F plasmid [3].

References

Regulation of traJ transcription in the Salmonella virulence plasmid by strand-specific DNA adenine hemimethylation. Camacho, E.M., Casadesús, J. Mol. Microbiol. (2005) [Pubmed]
Effects of Mutations and Truncations on the Kinetic Behavior of IIAGlc, a Phosphocarrier and Regulatory Protein of the Phosphoenolpyruvate Phosphotransferase System of Escherichia coli. Meadow, N.D., Savtchenko, R.S., Remington, S.J., Roseman, S. J. Biol. Chem. (2006) [Pubmed]
Nucleotide and amino acid sequences of oriT-traM-traJ-traY-traA-traL regions and mobilization of virulence plasmids of Salmonella enterica serovars enteritidis, gallinarum-pullorum, and typhimurium. Chu, C., Chiu, C.H., Chu, C.H., Ou, J.T. J. Bacteriol. (2002) [Pubmed]

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