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Gene Review:

Chil1 - chitinase-like 1

Mus musculus

Synonyms: AW208766, BRP39 protein, Breast regression protein 39, Brp39, CGP-39, ...

Kawada, M. et al., Colton, C.A. et al., Mizoguchi, E.

Colton, Mott, Sharpe, Xu, Van Nostrand, Vitek,

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Disease relevance of Chi3l1

Recently, we unexpectedly discovered significantly upregulated gene expression of chitinase 3-like-1 in inflamed colon of the dextran sulfate sodium-induced colitis model by employing the DNA-microarray analysis [1].

High impact information on Chi3l1

Chitinase 3-like-1 exacerbates intestinal inflammation by enhancing bacterial adhesion and invasion in colonic epithelial cells [2].
Chitinase 3-like-1 protein is mainly expressed in colonic epithelial cells and macrophages in the inflamed colon of dextran sulfate sodium-induced colitis [1].
Chitinase 3-like-1 has a chitin binding ability, but lacks the enzymatic activity of lysing microbial cell wall [1].
In AD brain, mRNAs for TNFalpha, AGI, MRC1 and the chitinase-3 like 1 and 2 genes (CHI3L1; CHI3L2) were significantly increased while NOS2 and IL-1beta mRNAs were unchanged [3].

References

Role of mammalian chitinases in inflammatory conditions. Kawada, M., Hachiya, Y., Arihiro, A., Mizoguchi, E. The Keio journal of medicine (2007) [Pubmed]
Chitinase 3-like-1 exacerbates intestinal inflammation by enhancing bacterial adhesion and invasion in colonic epithelial cells. Mizoguchi, E. Gastroenterology (2006) [Pubmed]
Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD. Colton, C.A., Mott, R.T., Sharpe, H., Xu, Q., Van Nostrand, W.E., Vitek, M.P. Journal of neuroinflammation [electronic resource]. (2006) [Pubmed]

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