The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Crkl  -  v-crk sarcoma virus CT10 oncogene homolog...

Mus musculus

Synonyms: 1110025F07Rik, AA589403, AI325100, Crk-like protein, Crkol
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Crkl


High impact information on Crkl


Biological context of Crkl


Enzymatic interactions of Crkl

  • Crkl is complexed with tyrosine-phosphorylated Cbl in Ph-positive leukemia [4].

Other interactions of Crkl

  • Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromes [7].
  • Both the expression of Crkl and the Stat5b binding ability are the highest in B6.NOD-c11 and the lowest in NOD while intermediate in B6 and NOD.Lc11 mice [2].


  1. Tyrosine phosphorylation of murine Crkl. de Jong, R., Haataja, L., Voncken, J.W., Heisterkamp, N., Groffen, J. Oncogene (1995) [Pubmed]
  2. Impaired Crkl expression contributes to the defective DNA binding of Stat5b in nonobese diabetic mice. Laloraya, M., Davoodi-Semiromi, A., Kumar, G.P., McDuffie, M., She, J.X. Diabetes (2006) [Pubmed]
  3. Global effects of BCR/ABL and TEL/PDGFRbeta expression on the proteome and phosphoproteome: identification of the Rho pathway as a target of BCR/ABL. Unwin, R.D., Sternberg, D.W., Lu, Y., Pierce, A., Gilliland, D.G., Whetton, A.D. J. Biol. Chem. (2005) [Pubmed]
  4. Crkl is complexed with tyrosine-phosphorylated Cbl in Ph-positive leukemia. de Jong, R., ten Hoeve, J., Heisterkamp, N., Groffen, J. J. Biol. Chem. (1995) [Pubmed]
  5. C3G is tyrosine-phosphorylated after integrin-mediated cell adhesion in normal but not in Bcr/Abl expressing cells. de Jong, R., van Wijk, A., Heisterkamp, N., Groffen, J. Oncogene (1998) [Pubmed]
  6. Microarray analysis of the Df1 mouse model of the 22q11 deletion syndrome. Prescott, K., Ivins, S., Hubank, M., Lindsay, E., Baldini, A., Scambler, P. Hum. Genet. (2005) [Pubmed]
  7. Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromes. Moon, A.M., Guris, D.L., Seo, J.H., Li, L., Hammond, J., Talbot, A., Imamoto, A. Dev. Cell (2006) [Pubmed]
WikiGenes - Universities