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Gene Review

Dpysl2  -  dihydropyrimidinase-like 2

Mus musculus

Synonyms: AI851130, Crmp2, DRP-2, DRP2, Dihydropyrimidinase-related protein 2, ...
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High impact information on Dpysl2

  • In cultures of highly purified oligodendrocytes, however, CRMP2/Ulip2 was detectable in all the cells [1].
  • Interestingly, in the adult, the protein CRMP2/Ulip2 is mainly detectable in subsets of oligodendrocytes distributed according to an increasing rostrocaudal gradient, with the largest number of positive cells being present in the brain stem and spinal cord [1].
  • Human DRP-2 showed 98% aa identity with chicken CRMP-62 (collapsin response mediator protein of relative molecular mass of 62 kDa) which is involved in neuronal growth cone collapse [2].
  • Collapsin response mediator protein-2 or Crmp-2 plays a critical role in the establishment of neuronal polarity [3].
  • We show that Crmp-2 undergoes dynamic phosphorylation changes in response to contact inhibition-induced quiescence and that hyperphosphorylation of Crmp-2 occurs in a tumor [3].

Biological context of Dpysl2

  • Collapsin response mediator proteins (CRMPs also known as TUC, Drp, Ulip, TOAD-64) are cytosolic phosphoproteins that are involved in signal transduction during axon growth and in cytoskeletal dynamics [4].
  • In this study, we present evidence that apart from its functions in neurodevelopment, Crmp-2 is also involved in pathways that regulate the proliferation of non-neuronal cells through its phosphorylation by regulatory proteins [3].

Other interactions of Dpysl2

  • The proteins identified were: heat shock protein 84 (HSP84), heat shock protein 70 (HSP70), dihydropyrimidinase-like protein-2 (DRP-2), creatine kinase (CK) and beta-actin [5].


  1. Differential expression of collapsin response mediator proteins (CRMP/ULIP) in subsets of oligodendrocytes in the postnatal rodent brain. Ricard, D., Stankoff, B., Bagnard, D., Aguera, M., Rogemond, V., Antoine, J.C., Spassky, N., Zalc, B., Lubetzki, C., Belin, M.F., Honnorat, J. Mol. Cell. Neurosci. (2000) [Pubmed]
  2. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. Hamajima, N., Matsuda, K., Sakata, S., Tamaki, N., Sasaki, M., Nonaka, M. Gene (1996) [Pubmed]
  3. Evidence for a role of Collapsin response mediator protein-2 in signaling pathways that regulate the proliferation of non-neuronal cells. Tahimic, C.G., Tomimatsu, N., Nishigaki, R., Fukuhara, A., Toda, T., Kaibuchi, K., Shiota, G., Oshimura, M., Kurimasa, A. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  4. Expression of collapsin response mediator proteins in the nervous system of embryonic zebrafish. Schweitzer, J., Becker, C.G., Schachner, M., Becker, T. Gene Expr. Patterns (2005) [Pubmed]
  5. Metallothionein-3 is a component of a multiprotein complex in the mouse brain. El Ghazi, I., Martin, B.L., Armitage, I.M. Exp. Biol. Med. (Maywood) (2006) [Pubmed]
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