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Gene Review

Dbp  -  D site albumin promoter binding protein

Mus musculus

Synonyms: Albumin D box-binding protein, Albumin D-element-binding protein, D site-binding protein
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Psychiatry related information on Dbp

  • Previous studies with mice deleted for the Dbp gene have established that DBP participates in the regulation of several clock outputs, including locomotor activity, sleep distribution, and liver gene expression [1].

High impact information on Dbp

  • Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions [2].
  • Thus, the Dbp transcription cycle is paralleled by binding of BMAL1 and CLOCK to multiple extra- and intragenic E boxes, acetylation of Lys9 of histone H3, trimethylation of Lys4 of histone H3 and a reduction of histone density [2].
  • Genetic and biochemical experiments suggest that CLOCK regulates Dbp expression by binding to E-box motifs within putative enhancer regions located in the first and second introns [1].
  • DBP is known to increase transcriptional level of cholesterol 7alpha-hydroxylase (C7alpha), the rate-limiting enzyme for bile acid production and cholesterol excretion, and we found that C7alpha mRNA was also up-regulated by LC omega-3 fatty acids [3].
  • In the present study, we compared clock-related gene expression (mPer1, mBmal1 and Dbp) in the SCN and peripheral tissues (liver, adrenal gland and heart) between CS and C57BL/6J mice [4].

Analytical, diagnostic and therapeutic context of Dbp

  • This study examines the distribution of Dbp epitopes in European strains of B. burgdorferi, of different genospecies and the presence of antibodies to Dbps in human sera from patients suffering from early and late LB, as revealed by immunoblotting [5].
  • Using cDNA microarrays, we assessed expression levels of 1176 genes, and we found that D-site binding protein (DBP) was three-fold increased in mice on a LC omega-3 fatty acid-rich diet compared to controls [3].


  1. CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP. Ripperger, J.A., Shearman, L.P., Reppert, S.M., Schibler, U. Genes Dev. (2000) [Pubmed]
  2. Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions. Ripperger, J.A., Schibler, U. Nat. Genet. (2006) [Pubmed]
  3. Dietary fish oil up-regulates cholesterol 7alpha-hydroxylase mRNA in mouse liver leading to an increase in bile acid and cholesterol excretion. Bérard, A.M., Dumon, M.F., Darmon, M. FEBS Lett. (2004) [Pubmed]
  4. Peripheral clock gene expression in CS mice with bimodal locomotor rhythms. Watanabe, T., Kojima, M., Tomida, S., Nakamura, T.J., Yamamura, T., Nakao, N., Yasuo, S., Yoshimura, T., Ebihara, S. Neurosci. Res. (2006) [Pubmed]
  5. Evidence of Dbps (decorin binding proteins) among European strains of Borrelia burgdorferi sensu lato and in the immune response of LB patient sera. Cinco, M., Ruscio, M., Rapagna, F. FEMS Microbiol. Lett. (2000) [Pubmed]
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