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Gene Review

DBP  -  D site of albumin promoter (albumin D-box)...

Homo sapiens

Synonyms: Albumin D box-binding protein, Albumin D-element-binding protein, D site-binding protein, DABP, Tax-responsive enhancer element-binding protein 302, ...
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Disease relevance of DBP


Psychiatry related information on DBP

  • RESULTS: Systolic BP (SBP) was linearly related significantly to BMI and alcohol consumption, whereas diastolic BP (DBP) was related to age [6].
  • The UV/TiO(2)/glass process yielded a 75% degradation efficiency of DBP with initial concentration of 5mgL(-1) at 80min reaction time [7].

High impact information on DBP


Chemical compound and disease context of DBP


Biological context of DBP

  • A naturally occurring variant of DBP (tDBP), lacking the transactivation domain, has been identified and shown to impede the formation of active TEF dimers in a competitive manner and to reduce the TEF-dependent induction of bcl-gS [17].
  • TEF and DBP control elements have never been investigated in the insulin-secreting cells, but impairment of the circadian rhythm of the beta-cells might be involved in the development of diabetic state as type 2 diabetics have lost daily temporal variations of insulin secretion [18].
  • These data confirmed by molecular genetic analysis highlight the novel association between the C677T MTHFR genotype with the Gc2 polymorphism of the DBP [19].
  • In vitro, TEF and DBP bind the same DNA sequences [20].
  • In this study, the functional role of DBP and C/EBP (which have several potential binding sites on the IGFBP-1 proximal promoter) have been investigated [21].

Anatomical context of DBP


Associations of DBP with chemical compounds

  • Finally, these studies reaffirm the potential role of dimeric transcription factor complexes in mediating interactions with specific promoter elements, which, in the case of the Factor VIII promoter, results in dramatically enhanced binding of HLF-DBP heterodimers to two cis-acting sequences [1].
  • D-site binding protein transactivation requires the proline- and acid-rich domain and involves the coactivator p300 [24].
  • Seated systolic BP (SBP) and diastolic BP (DBP) were measured using a standard mercury sphygmomanometer [4].
  • Di-n-butyl phthalate (DBP) is one of the most dominant phthalate esters and is widely distributed environmental contaminant [25].
  • Moreover, neutrophils treated with LPS bound more avidity to immobilized DBP than sham-treated cells [23].

Physical interactions of DBP

  • We have previously demonstrated that the Adenovirus 2 DNA Binding Protein (DBP) binds to SrCap and inhibits the transcription mediated by the carboxyl-terminal region of SrCap (amino acids 1275-2971) [26].
  • We have used a 5' regulatory sequence fragment of the human parathyroid hormone-related peptide (PTHrP) gene to identify nuclear DNA-binding proteins (DBP), using South-Western analysis [27].
  • We previously reported the isolation and functional characterization of seven adenovirus type 5 (Ad5) DNA-binding protein (DBP) point mutants (Quinn, C. O., and Kitchingman, G. R. (1986) J. Virol. 60, 653-661) [28].

Regulatory relationships of DBP

  • In addition, DBP also inhibits the ability of SrCap to enhance Protein Kinase A (PKA) activated transcription of the enkaphalin promoter [26].

Other interactions of DBP

  • Enhanced binding of HLF/DBP heterodimers represents one mechanism of PAR protein transactivation of the factor VIII and factor IX genes [1].
  • The D-site binding protein (DBP) is a member of the proline- and acid-rich (PAR) domain subfamily of basic/leucine zipper proteins and is involved in transcriptional regulation in the liver [24].
  • Furthermore, the AGTR1 L191 allele showed a SBP lowering effect in subjects with a high socioeconomic status (SES;p = .048) and a DBP lowering effect in AAs (p = .038) [29].
  • These studies suggest that HNF-1 and C/EBP alpha help establish ADH gene family transcription in fetal liver and that LAP and DBP help maintain high-level ADH gene family transcription in postnatal liver [30].
  • In patients, DBP decreased slightly and MBP dropped during the first 2 minutes, then increased [31].

Analytical, diagnostic and therapeutic context of DBP


  1. Enhanced binding of HLF/DBP heterodimers represents one mechanism of PAR protein transactivation of the factor VIII and factor IX genes. Begbie, M., Mueller, C., Lillicrap, D. DNA Cell Biol. (1999) [Pubmed]
  2. Binding of the Ets factor GA-binding protein to an upstream site in the factor IX promoter is a critical event in transactivation. Boccia, L.M., Lillicrap, D., Newcombe, K., Mueller, C.R. Mol. Cell. Biol. (1996) [Pubmed]
  3. Cloning of a cDNA encoding a DNA-binding protein TAXREB302 that is specific for the tax-responsive enhancer of HTLV-I. Nyunoya, H., Morita, T., Sato, T., Honma, S., Tsujimoto, A., Shimotohno, K. Gene (1994) [Pubmed]
  4. Lower bone mineral content in hypertensive compared with normotensive overweight latino children and adolescents. Afghani, A., Goran, M.I. Am. J. Hypertens. (2007) [Pubmed]
  5. Locus of control predicts appraisals and cardiovascular reactivity to a novel active coping task. Weinstein, S.E., Quigley, K.S. Journal of personality. (2006) [Pubmed]
  6. Is high job strain associated with hypertension genesis? Ducher, M., Cerutti, C., Chatellier, G., Fauvel, J.P. Am. J. Hypertens. (2006) [Pubmed]
  7. Degradation of di-n-butyl phthalate using photoreactor packed with TiO(2) immobilized on glass beads. Chiou, C.S., Shie, J.L., Chang, C.Y., Liu, C.C., Chang, C.T. J. Hazard. Mater. (2006) [Pubmed]
  8. Synergy between transcription factors DBP and C/EBP compensates for a haemophilia B Leyden factor IX mutation. Picketts, D.J., Lillicrap, D.P., Mueller, C.R. Nat. Genet. (1993) [Pubmed]
  9. Liver-enriched transcription factors in liver function and development. Part II: the C/EBPs and D site-binding protein in cell cycle control, carcinogenesis, circadian gene regulation, liver regeneration, apoptosis, and liver-specific gene regulation. Schrem, H., Klempnauer, J., Borlak, J. Pharmacol. Rev. (2004) [Pubmed]
  10. The crystal structure of P. knowlesi DBPalpha DBL domain and its implications for immune evasion. McHenry, A.M., Adams, J.H. Trends Biochem. Sci. (2006) [Pubmed]
  11. Multimerization of the adenovirus DNA-binding protein is the driving force for ATP-independent DNA unwinding during strand displacement synthesis. Dekker, J., Kanellopoulos, P.N., Loonstra, A.K., van Oosterhout, J.A., Leonard, K., Tucker, P.A., van der Vliet, P.C. EMBO J. (1997) [Pubmed]
  12. The liver-enriched transcription factor D-site-binding protein activates the promoter of the phosphoenolpyruvate carboxykinase gene in hepatoma cells. Roesler, W.J., McFie, P.J., Dauvin, C. J. Biol. Chem. (1992) [Pubmed]
  13. Adenovirus type 2 coded single-stranded DNA binding protein: in vivo phosphorylation and modification. Jeng, Y.H., Wold, W.S., Sugawara, K., Gilead, Z., Green, M. J. Virol. (1977) [Pubmed]
  14. Delapril/manidipine. McCormack, P.L., Keating, G.M. Drugs (2006) [Pubmed]
  15. Phosphorylation of adenovirus DNA-binding protein. Russell, W.C., Webster, A., Leith, I.R., Kemp, G.D. J. Gen. Virol. (1989) [Pubmed]
  16. Effects of phthalate esters on dendritic cell subsets and interleukin-4 production in fluorescein isothiocyanate-induced contact hypersensitivity. Maruyama, T., Shiba, T., Iizuka, H., Matsuda, T., Kurohane, K., Imai, Y. Microbiol. Immunol. (2007) [Pubmed]
  17. A Novel Role for Proline- and Acid-rich Basic Region Leucine Zipper (PAR bZIP) Proteins in the Transcriptional Regulation of a BH3-only Proapoptotic Gene. Benito, A., Gutierrez, O., Pipaon, C., Real, P.J., Gachon, F., Ritchie, A.E., Fernandez-Luna, J.L. J. Biol. Chem. (2006) [Pubmed]
  18. Circadian regulation of islet genes involved in insulin production and secretion. Allaman-Pillet, N., Roduit, R., Oberson, A., Abdelli, S., Ruiz, J., Beckmann, J.S., Schorderet, D.F., Bonny, C. Mol. Cell. Endocrinol. (2004) [Pubmed]
  19. A proteomic approach for the characterization of C677T mutation of the human gene methylenetetrahydrofolate reductase. Greco, M., Chiriac??, F., Del Boccio, P., Tagliaferro, L., Acierno, R., Menegazzi, P., Pinca, E., Pignatelli, F., Storelli, C., Federici, G., Urbani, A., Maffia, M. Proteomics (2006) [Pubmed]
  20. The two PAR leucine zipper proteins, TEF and DBP, display similar circadian and tissue-specific expression, but have different target promoter preferences. Fonjallaz, P., Ossipow, V., Wanner, G., Schibler, U. EMBO J. (1996) [Pubmed]
  21. Interplay of the liver-enriched trans-acting factors, DBP and HNF1, in the transactivation of human IGFBP-1 promoter. Babajko, S., Groyer, A. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  22. Competition between transcription factors HNF1 and HNF3, and alternative cell-specific activation by DBP and C/EBP contribute to the regulation of the liver-specific aldolase B promoter. Gregori, C., Kahn, A., Pichard, A.L. Nucleic Acids Res. (1993) [Pubmed]
  23. Upregulation of Vitamin D binding protein (Gc-globulin) binding sites during neutrophil activation from a latent reservoir in azurophil granules. Dimartino, S.J., Trujillo, G., McVoy, L.A., Zhang, J., Kew, R.R. Mol. Immunol. (2007) [Pubmed]
  24. D-site binding protein transactivation requires the proline- and acid-rich domain and involves the coactivator p300. Lamprecht, C., Mueller, C.R. J. Biol. Chem. (1999) [Pubmed]
  25. Low concentrations mono-butyl phthalate stimulates steroidogenesis by facilitating steroidogenic acute regulatory protein expression in mouse Leydig tumor cells (MLTC-1). Wang, Y., Song, L., Hong, X., Cui, L., Zhang, Z., Xiao, H., Zhou, J., Wang, X. Chem. Biol. Interact. (2006) [Pubmed]
  26. Adenovirus DNA binding protein inhibits SrCap-activated CBP and CREB-mediated transcription. Xu, X., Tarakanova, V., Chrivia, J., Yaciuk, P. Virology (2003) [Pubmed]
  27. Two nuclear proteins bind to the promoter P3 region of the human parathyroid hormone-related peptide gene. Bui, T.D., Woe, H.Y., Khan, I., Burton, P.B., Moniz, C.F. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  28. Biochemical analysis of adenovirus type 5 DNA-binding protein mutants. Neale, G.A., Kitchingman, G.R. J. Biol. Chem. (1989) [Pubmed]
  29. Effects of angiotensinogen and angiotensin II type I receptor genes on blood pressure and left ventricular mass trajectories in multiethnic youth. Wang, X., Zhu, H., Dong, Y., Treiber, F.A., Snieder, H. Twin research and human genetics : the official journal of the International Society for Twin Studies. (2006) [Pubmed]
  30. Temporal expression of the human alcohol dehydrogenase gene family during liver development correlates with differential promoter activation by hepatocyte nuclear factor 1, CCAAT/enhancer-binding protein alpha, liver activator protein, and D-element-binding protein. van Ooij, C., Snyder, R.C., Paeper, B.W., Duester, G. Mol. Cell. Biol. (1992) [Pubmed]
  31. Transcranial doppler ultrasonographic evaluation of cerebral circulation during passive tilting in patients with Parkinson's disease. Mihci, E., Dora, B., Balkan, S. Journal of clinical ultrasound : JCU (2007) [Pubmed]
  32. Identification of group specific component/vitamin D-binding protein (GC/DBP) mutants by isoelectric focusing in immobilized pH gradients. Constans, J., Cleve, H. Electrophoresis (1988) [Pubmed]
  33. Two functions encoded by adenovirus early region 1A are responsible for the activation and repression of the DNA-binding protein gene. Guilfoyle, R.A., Osheroff, W.P., Rossini, M. EMBO J. (1985) [Pubmed]
  34. Association of the adenovirus DNA-binding protein with RNA both in vitro and in vivo. Cleghon, V.G., Klessig, D.F. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  35. Nuclear localization of the adenovirus DNA-binding protein: requirement for two signals and complementation during viral infection. Morin, N., Delsert, C., Klessig, D.F. Mol. Cell. Biol. (1989) [Pubmed]
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