The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Rhodanid     thiocyanate

Synonyms: Thiozyanat, thiocyanide, HSCN, sulphocyanate, NCS-, ...
This record was replaced with 781.
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of thiocyanic acid


Psychiatry related information on thiocyanic acid


High impact information on thiocyanic acid

  • Why the rat-1 fibroblast should replace the SCN as the in vitro model of choice [11].
  • Schwartz et al (1987) have presented evidence that the circadian pacemaker in the SCN continues to run, but cannot be entrained by light, when tetrodotoxin is used to block sodium-dependent action potentials [12].
  • Here we show that temporal feeding restriction under light-dark or dark-dark conditions can change the phase of circadian gene expression in peripheral cell types by up to 12 h while leaving the phase of cyclic gene expression in the SCN unaffected [13].
  • Response to Honma and Honma: do circadian rhythms in cytosolic Ca2+ modulate autonomous gene transcription cycles in the SCN [14]?
  • The suprachiasmatic nuclei of the hypothalamus (SCN) are well established as the principal circadian oscillator of mammals [15].

Chemical compound and disease context of thiocyanic acid


Biological context of thiocyanic acid


Anatomical context of thiocyanic acid


Associations of thiocyanic acid with other chemical compounds


Gene context of thiocyanic acid

  • Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock [35].
  • Both Per1 and Per2 RNAs in the SCN are increased by light exposure during subjective night but not during subjective day [36].
  • Pre-incubation of SCN- with MPO generates a more complex biological setting, because SCN- serves as either a substrate or inhibitor, causing diverse impacts on the MPO heme iron microenvironment [37].
  • This study for the first time presents transient kinetic measurements of the formation of compound I of human eosinophil peroxidase (EPO) and its reaction with halides and thiocyanate, using the sequential-mixing stopped-flow technique [38].
  • Corneal and conjunctival epithelia were lysed in RIPA buffer for Western blot with MAPK antibodies, or they were lysed in 4 M guanidium thiocyanate solution for extraction of total RNA, which was used to determine gene expression by semiquantitative RT-PCR, real-time PCR, and gene array [39].

Analytical, diagnostic and therapeutic context of thiocyanic acid

  • We used ELISA with potassium thiocyanate to compare the average avidity of antibody produced by infants with that of children older than 10 years after systemic disease [40].
  • The quantitation of vasopressin mRNA was achieved by using three different procedures: (1) cell-free translation in rabbit reticulocyte lysate or (2) Northern analysis of poly(A)RNAs isolated from micro-punch dissected SON, PVN, and SCN, and (3) in situ hybridization histochemistry [32].
  • Choroidal perfusion with each of 4 anion transport and Cl- channel blockers (DIDS, 4-acetamido-4'-isothiocyanostilbene, phenylanthranylic acid, and thiocyanate) suppressed the light peak [41].
  • PRR titrations enabled the measurement of binding of creatine to the ternary CH3S-enzyme-MnADP complex and show that specific anions such as nitrate, formate, and thiocyanate decrease the apparent dissociation constant for creatine in its complex with the CH3S-blocked enzyme and MnADP, as is observed with native creatine kinase [42].
  • Using microdialysis probes we measured nitrite, ascorbic acid, total vitamin C, and thiocyanate concentrations and pH simultaneously in the proximal oesophagus, Barrett's segment, hiatal sac, proximal stomach, and distal stomach [43].


  1. Viricidal effect of Lactobacillus acidophilus on human immunodeficiency virus type 1: possible role in heterosexual transmission. Klebanoff, S.J., Coombs, R.W. J. Exp. Med. (1991) [Pubmed]
  2. Induction of mouse lung adenomas by amines or ureas plus nitrite and by N-nitroso compounds: effect of ascorbate, gallic acid, thiocyanate, and caffeine. Mirvish, S.S., Cardesa, A., Wallcave, L., Shubik, P. J. Natl. Cancer Inst. (1975) [Pubmed]
  3. Association of high cyanide and low sulphur intake in cassava-induced spastic paraparesis. Cliff, J., Lundqvist, P., Mårtensson, J., Rosling, H., Sörbo, B. Lancet (1985) [Pubmed]
  4. Ultrastructural changes and cyclic AMP in frog oxyntic cells. Carlisle, K.S., Chew, C.S., Hersey, S.J. J. Cell Biol. (1978) [Pubmed]
  5. Thiocyanate and hydroxyl ions inactivate the scrapie agent. Prusiner, S.B., Groth, D.F., McKinley, M.P., Cochran, S.P., Bowman, K.A., Kasper, K.C. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  6. Effect of SCN lesions on sleep in squirrel monkeys: evidence for opponent processes in sleep-wake regulation. Edgar, D.M., Dement, W.C., Fuller, C.A. J. Neurosci. (1993) [Pubmed]
  7. Forced desynchronization of dual circadian oscillators within the rat suprachiasmatic nucleus. de la Iglesia, H.O., Cambras, T., Schwartz, W.J., Díez-Noguera, A. Curr. Biol. (2004) [Pubmed]
  8. Circadian regulation of sleep in mammals: role of the suprachiasmatic nucleus. Mistlberger, R.E. Brain Res. Brain Res. Rev. (2005) [Pubmed]
  9. Smoking cessation program: baseline carbon monoxide and serum thiocyanate levels as predictors of outcome. Vogt, T.M., Selvin, S., Billings, J.H. American journal of public health. (1979) [Pubmed]
  10. Fos-immunoreactivity in the hypothalamus: dependency on the diurnal rhythm, sleep, gender, and estrogen. Peterfi, Z., Churchill, L., Hajdu, I., Obal Jr, F., Krueger, J.M., Parducz, A. Neuroscience (2004) [Pubmed]
  11. Why the rat-1 fibroblast should replace the SCN as the in vitro model of choice. Rosbash, M. Cell (1998) [Pubmed]
  12. Neurotransmitters in the mammalian circadian system. Rusak, B., Bina, K.G. Annu. Rev. Neurosci. (1990) [Pubmed]
  13. Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., Schibler, U. Genes Dev. (2000) [Pubmed]
  14. Response to Honma and Honma: do circadian rhythms in cytosolic Ca2+ modulate autonomous gene transcription cycles in the SCN? Ikeda, M. Trends Neurosci. (2003) [Pubmed]
  15. Central clocking. Hastings, M.H. Trends Neurosci. (1997) [Pubmed]
  16. A thiocyanate hydrolase of Thiobacillus thioparus. A novel enzyme catalyzing the formation of carbonyl sulfide from thiocyanate. Katayama, Y., Narahara, Y., Inoue, Y., Amano, F., Kanagawa, T., Kuraishi, H. J. Biol. Chem. (1992) [Pubmed]
  17. Leisure-time physical activity is inversely related to risk factors for coronary heart disease in middle-aged Finnish men. Tuomilehto, J., Marti, B., Salonen, J.T., Virtala, E., Lahti, T., Puska, P. Eur. Heart J. (1987) [Pubmed]
  18. Anticooperative ligand binding properties of recombinant ferric Vitreoscilla homodimeric hemoglobin: a thermodynamic, kinetic and X-ray crystallographic study. Bolognesi, M., Boffi, A., Coletta, M., Mozzarelli, A., Pesce, A., Tarricone, C., Ascenzi, P. J. Mol. Biol. (1999) [Pubmed]
  19. Some aspects of sodium nitroprusside reaction with human erythrocytes. Spiegel, H.E., Kucera, V. Clin. Chem. (1977) [Pubmed]
  20. N-nitrosation of proline in smokers and nonsmokers. Ladd, K.F., Newmark, H.L., Archer, M.C. J. Natl. Cancer Inst. (1984) [Pubmed]
  21. Goitrous endemic in Guinea. Konde, M., Ingenbleek, Y., Daffe, M., Sylla, B., Barry, O., Diallo, S. Lancet (1994) [Pubmed]
  22. Membrane potential of Plasmodium-infected erythrocytes. Mikkelsen, R.B., Tanabe, K., Wallach, D.F. J. Cell Biol. (1982) [Pubmed]
  23. Down-regulation of pituitary receptors for luteinizing hormone-releasing hormone (LH-RH) in rats by LH-RH antagonist Cetrorelix. Halmos, G., Schally, A.V., Pinski, J., Vadillo-Buenfil, M., Groot, K. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  24. Increasing binding affinity of agonists to glutamate receptors increases synaptic responses at glutamatergic synapses. Shahi, K., Baudry, M. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  25. 2,4-Dichlorobenzyl thiocyanate, an antimitotic agent that alters microtubule morphology. Abraham, I., Dion, R.L., Chi, D.M., Gottesman, M.M., Hamel, E. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  26. Membrane potential depolarization and increased intracellular pH accompany the acrosome reaction of sea urchin sperm. Schackmann, R.W., Christen, R., Shapiro, B.M. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  27. The role of glutamate in the photic regulation of the suprachiasmatic nucleus. Ebling, F.J. Prog. Neurobiol. (1996) [Pubmed]
  28. Thermosensitivity of the membrane potential of normal and simian virus 40-transformed hamster lymphocytes. Mikkelsen, R.B., Koch, B. Cancer Res. (1981) [Pubmed]
  29. Gene expression in a subpopulation of luteinizing hormone-releasing hormone (LHRH) neurons prior to the preovulatory gonadotropin surge. Porkka-Heiskanen, T., Urban, J.H., Turek, F.W., Levine, J.E. J. Neurosci. (1994) [Pubmed]
  30. The hydration structure of guanidinium and thiocyanate ions: implications for protein stability in aqueous solution. Mason, P.E., Neilson, G.W., Dempsey, C.E., Barnes, A.C., Cruickshank, J.M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  31. Metabolism of acrylonitrile by isolated rat hepatocytes. Geiger, L.E., Hogy, L.L., Guengerich, F.P. Cancer Res. (1983) [Pubmed]
  32. Vasopressin mRNA regulation in individual hypothalamic nuclei: a northern and in situ hybridization analysis. Sherman, T.G., McKelvy, J.F., Watson, S.J. J. Neurosci. (1986) [Pubmed]
  33. Phenethyl isothiocyanate triggers apoptosis in Jurkat cells made resistant by the overexpression of Bcl-2. Thomson, S.J., Brown, K.K., Pullar, J.M., Hampton, M.B. Cancer Res. (2006) [Pubmed]
  34. Bactericidal activity of eosinophil peroxidase. Jong, E.C., Henderson, W.R., Klebanoff, S.J. J. Immunol. (1980) [Pubmed]
  35. Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Bae, K., Jin, X., Maywood, E.S., Hastings, M.H., Reppert, S.M., Weaver, D.R. Neuron (2001) [Pubmed]
  36. Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei. Shearman, L.P., Zylka, M.J., Weaver, D.R., Kolakowski, L.F., Reppert, S.M. Neuron (1997) [Pubmed]
  37. Thiocyanate modulates the catalytic activity of mammalian peroxidases. Tahboub, Y.R., Galijasevic, S., Diamond, M.P., Abu-Soud, H.M. J. Biol. Chem. (2005) [Pubmed]
  38. Spectral and kinetic studies on the formation of eosinophil peroxidase compound I and its reaction with halides and thiocyanate. Furtmüller, P.G., Burner, U., Regelsberger, G., Obinger, C. Biochemistry (2000) [Pubmed]
  39. Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface. Luo, L., Li, D.Q., Doshi, A., Farley, W., Corrales, R.M., Pflugfelder, S.C. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  40. Production of low-avidity antibody by infants after infection with serogroup B meningococci. Pollard, A.J., Levin, M. Lancet (2000) [Pubmed]
  41. Effects of DIDS on the chick retinal pigment epithelium. II. Mechanism of the light peak and other responses originating at the basal membrane. Gallemore, R.P., Steinberg, R.H. J. Neurosci. (1989) [Pubmed]
  42. Magnetic resonance studies of three forms of creatine kinase. Comparison of the properties of native, CH-S-blocked, and H2NCOCH-blocked enzymes. Markham, G.D., Reed, G.H. J. Biol. Chem. (1977) [Pubmed]
  43. Nitrate and nitrosative chemistry within Barrett's oesophagus during acid reflux. Suzuki, H., Iijima, K., Scobie, G., Fyfe, V., McColl, K.E. Gut (2005) [Pubmed]
WikiGenes - Universities