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Gene Review

Dsc1  -  desmocollin 1

Mus musculus

Synonyms: Desmocollin-1, Dsc1a, Dsc1b
 
 
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Disease relevance of Dsc1

 

High impact information on Dsc1

 

Biological context of Dsc1

 

Anatomical context of Dsc1

 

Other interactions of Dsc1

  • We suggest that it is the ratio of desmocollin 1 to desmocollin 3 expression at different levels in the epidermis that is fundamental in establishing this pattern of differentiation [7].
  • Dsc3 expression is strongest in basal cell layers, whereas Dsc1 is largely confined to upper, terminally differentiating strata [5].
 

Analytical, diagnostic and therapeutic context of Dsc1

References

  1. Human desmocollin 1a transiently expressed in COS-7 cells and NIH 3T3-3 cells is reacted by IgG4 antibodies in a pemphigus foliaceus serum. Dmochowski, M., Nie, Z., Kiyokawa, C., Hashimoto, T. J. Dermatol. Sci. (1999) [Pubmed]
  2. Desmosomal cadherin misexpression alters beta-catenin stability and epidermal differentiation. Hardman, M.J., Liu, K., Avilion, A.A., Merritt, A., Brennan, K., Garrod, D.R., Byrne, C. Mol. Cell. Biol. (2005) [Pubmed]
  3. Assessment of splice variant-specific functions of desmocollin 1 in the skin. Cheng, X., Mihindukulasuriya, K., Den, Z., Kowalczyk, A.P., Calkins, C.C., Ishiko, A., Shimizu, A., Koch, P.J. Mol. Cell. Biol. (2004) [Pubmed]
  4. Regulation of desmocollin transcription in mouse preimplantation embryos. Collins, J.E., Lorimer, J.E., Garrod, D.R., Pidsley, S.C., Buxton, R.S., Fleming, T.P. Development (1995) [Pubmed]
  5. Regulation of desmocollin gene expression in the epidermis: CCAAT/enhancer-binding proteins modulate early and late events in keratinocyte differentiation. Smith, C., Zhu, K., Merritt, A., Picton, R., Youngs, D., Garrod, D., Chidgey, M. Biochem. J. (2004) [Pubmed]
  6. Keratin 8 modulation of desmoplakin deposition at desmosomes in hepatocytes. Loranger, A., Gilbert, S., Brouard, J.S., Magin, T.M., Marceau, N. Exp. Cell Res. (2006) [Pubmed]
  7. Changing pattern of desmocollin 3 expression accompanies epidermal organisation during skin development. Chidgey, M.A., Yue, K.K., Gould, S., Byrne, C., Garrod, D.R. Dev. Dyn. (1997) [Pubmed]
  8. Characterization of desmosomal component expression during palatogenesis. Mogass, M., Bringas, P., Shuler, C.F. Int. J. Dev. Biol. (2000) [Pubmed]
 
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