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Gene Review

Dyrk1a  -  dual-specificity tyrosine-(Y)...

Mus musculus

Synonyms: 2310043O08Rik, D16Ertd272e, D16Ertd493e, Dual specificity YAK1-related kinase, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, ...
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Disease relevance of Dyrk1a

  • Our observations of calcineurin-and Nfatc-deficient mice, Dscr1- and Dyrk1a-overexpressing mice, mouse models of Down's syndrome and human trisomy 21 are consistent with these predictions [1].

High impact information on Dyrk1a

  • To investigate the cellular role of dual specificity Yak1-related kinase (Dyrk) 1, a nuclear localized dual specificity protein kinase, we examined its effect on transcriptional regulation using reporter gene assays [2].
  • We have previously shown DYRK1A expression in the cerebellum and functionally related structures, most brainstem motor nuclei and spinal cord, supporting a role for Dyrk1a in controlling motor function [3].
  • AVAILABILITY: F-values and real TFBS occurrences calculated for human, chimp, mouse, rat, zebrafish and fugu genomes are available for free download at[4]
  • Conditions under which segments of genes on chromosome 16 (App and Dyrk1a) could be coamplified with a control gene on chromosome 8 (Acta1) so that the yield of each PCR product was proportional to the amount of its template were determined [5].
  • The murine Dyrk protein maps to chromosome 16, localizes to the nucleus, and can form multimers [6].

Anatomical context of Dyrk1a

  • 2. (2) The Dyrk protein localizes to the cell nucleus, affording the potential of controlling the expression of other gene(s) [6].


  1. NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Arron, J.R., Winslow, M.M., Polleri, A., Chang, C.P., Wu, H., Gao, X., Neilson, J.R., Chen, L., Heit, J.J., Kim, S.K., Yamasaki, N., Miyakawa, T., Francke, U., Graef, I.A., Crabtree, G.R. Nature (2006) [Pubmed]
  2. Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1. Mao, J., Maye, P., Kogerman, P., Tejedor, F.J., Toftgard, R., Xie, W., Wu, G., Wu, D. J. Biol. Chem. (2002) [Pubmed]
  3. Motor phenotypic alterations in TgDyrk1a transgenic mice implicate DYRK1A in Down syndrome motor dysfunction. Martínez de Lagrán, M., Altafaj, X., Gallego, X., Martí, E., Estivill, X., Sahún, I., Fillat, C., Dierssen, M. Neurobiol. Dis. (2004) [Pubmed]
  4. A comparative analysis of relative occurrence of transcription factor binding sites in vertebrate genomes and gene promoter areas. Stepanova, M., Tiazhelova, T., Skoblov, M., Baranova, A. Bioinformatics (2005) [Pubmed]
  5. Polymerase chain reaction method to identify Down syndrome model segmentally trisomic mice. Ramakrishna, N., Meeker, C., Li, S., Jenkins, E.C., Currie, J.R., Flory, M., Lee, B., Liu, M.S., Miller, D.L. Anal. Biochem. (2005) [Pubmed]
  6. The murine Dyrk protein maps to chromosome 16, localizes to the nucleus, and can form multimers. Song, W.J., Chung, S.H., Kurnit, D.M. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
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