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Gene Review

MPLKIP  -  M-phase specific PLK1 interacting protein

Homo sapiens

Synonyms: ABHS, C7orf11, M-phase-specific PLK1-interacting protein, ORF20, TTD non-photosensitive 1 protein, ...
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Disease relevance of C7orf11

  • In addition, gene products from MHV68 ORF20, ORF24, ORF28, ORF45, ORF48, and ORF52 were identified in association with virions, suggesting that these gammaherpesvirus genes are involved in the early phase of infection or virion assembly and egress [1].

High impact information on C7orf11


Biological context of C7orf11


Associations of C7orf11 with chemical compounds

  • Remarkably for a tyrosine recombinase, Tn916 Int acts as a specificity factor in the reaction, conferring both strand and sequence specificities on the endonucleolytic cleavage activity of Orf20 [3].

Other interactions of C7orf11

  • This motif lies immediately adjacent to a sequence in oriT previously shown to be protected from DNase I cleavage by Int. The endonucleolytic cleavages produced by Orf20 generated a 3' OH group that could be radiolabeled by dideoxy ATP and terminal transferase [3].

Analytical, diagnostic and therapeutic context of C7orf11


  1. Identification of proteins associated with murine gammaherpesvirus 68 virions. Bortz, E., Whitelegge, J.P., Jia, Q., Zhou, Z.H., Stewart, J.P., Wu, T.T., Sun, R. J. Virol. (2003) [Pubmed]
  2. Identification of C7orf11 (TTDN1) gene mutations and genetic heterogeneity in nonphotosensitive trichothiodystrophy. Nakabayashi, K., Amann, D., Ren, Y., Saarialho-Kere, U., Avidan, N., Gentles, S., MacDonald, J.R., Puffenberger, E.G., Christiano, A.M., Martinez-Mir, A., Salas-Alanis, J.C., Rizzo, R., Vamos, E., Raams, A., Les, C., Seboun, E., Jaspers, N.G., Beckmann, J.S., Jackson, C.E., Scherer, S.W. Am. J. Hum. Genet. (2005) [Pubmed]
  3. The integrase of the conjugative transposon Tn916 directs strand- and sequence-specific cleavage of the origin of conjugal transfer, oriT, by the endonuclease Orf20. Rocco, J.M., Churchward, G. J. Bacteriol. (2006) [Pubmed]
  4. Mutations in the C7orf11 (TTDN1) gene in six nonphotosensitive trichothiodystrophy patients: no obvious genotype-phenotype relationships. Botta, E., Offman, J., Nardo, T., Ricotti, R., Zambruno, G., Sansone, D., Balestri, P., Raams, A., Kleijer, W.J., Jaspers, N.G., Sarasin, A., Lehmann, A.R., Stefanini, M. Hum. Mutat. (2007) [Pubmed]
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