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Gene Review:

Enc1 - ectodermal-neural cortex 1

Mus musculus

Synonyms: ENC-1, Ectoderm-neural cortex protein 1, Enc-1, Nrpb, PIG10

Hernandez, M.C. et al., Katayama, Y. et al., Hernandez, M. et al., García-Calero, E. et al.

García-Calero, Puelles,

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High impact information on Enc1

ENC-1 functions as an actin-binding protein that may be important in the organization of the actin cytoskeleton during neural fate specification and development of the NS [1].
Cellular expression of epitope-tagged ENC-1 shows extensive co-localization of ENC-1 with the actin cytoskeleton, and immunoprecipitation studies demonstrate a physical association between ENC-1 and actin [1].
The only apparent expression of ENC-1 outside the NS is restricted to the rostral-most somitomere of the presomitic mesoderm, at the times corresponding to the epithelialization that precedes somite formation [1].
CD27-CD70 interaction could not induce apoptosis in either type of myeloma transfectant, and binding between Siva and CD27 was not detected. cDNA microarray (human apoptosis CHIP) analysis showed a significant upregulation of expression of the ectodermal neural cortex 1 (ENC1) gene by CD27-CD70 interaction compared with CD27 transfection alone [2].
Pallial expression of Enc1 RNA in postnatal mouse telencephalon [3].

Biological context of Enc1

Assignment of the ectodermal-neural cortex 1 gene (Enc1) to mouse chromosome band 13D1 by fluorescence in situ hybridization [4].

References

ENC-1: a novel mammalian kelch-related gene specifically expressed in the nervous system encodes an actin-binding protein. Hernandez, M.C., Andres-Barquin, P.J., Martinez, S., Bulfone, A., Rubenstein, J.L., Israel, M.A. J. Neurosci. (1997) [Pubmed]
A possible role for the loss of CD27-CD70 interaction in myelomagenesis. Katayama, Y., Sakai, A., Oue, N., Asaoku, H., Otsuki, T., Shiomomura, T., Masuda, R., Hino, N., Takimoto, Y., Imanaka, F., Yasui, W., Kimura, A. Br. J. Haematol. (2003) [Pubmed]
Pallial expression of Enc1 RNA in postnatal mouse telencephalon. García-Calero, E., Puelles, L. Brain Res. Bull. (2005) [Pubmed]
Assignment of the ectodermal-neural cortex 1 gene (Enc1) to mouse chromosome band 13D1 by fluorescence in situ hybridization. Hernandez, M., Andres-Barquin, P.J., Israel, M.A. Cytogenet. Cell Genet. (2000) [Pubmed]

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