Gene Review:
Pfn1 - profilin 1
Mus musculus
Synonyms:
Pfn, Profilin I, Profilin-1, actin binding protein
- Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics. Gertler, F.B., Niebuhr, K., Reinhard, M., Wehland, J., Soriano, P. Cell (1996)
- Molecular cloning and characterization of profilin-3: a novel cytoskeleton-associated gene expressed in rat kidney and testes. Hu, E., Chen, Z., Fredrickson, T., Zhu, Y. Exp. Nephrol. (2001)
- Actin structural proteins in cell motility. Cunningham, C.C. Cancer Metastasis Rev. (1992)
- Actinin-4 increases cell motility and promotes lymph node metastasis of colorectal cancer. Honda, K., Yamada, T., Hayashida, Y., Idogawa, M., Sato, S., Hasegawa, F., Ino, Y., Ono, M., Hirohashi, S. Gastroenterology (2005)
- MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta. Woodings, J.A., Sharp, S.J., Machesky, L.M. Biochem. J. (2003)
- Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysis. Romero, S., Le Clainche, C., Didry, D., Egile, C., Pantaloni, D., Carlier, M.F. Cell (2004)
- Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin. Witke, W., Sharpe, A.H., Hartwig, J.H., Azuma, T., Stossel, T.P., Kwiatkowski, D.J. Cell (1995)
- Enhanced motility in NIH 3T3 fibroblasts that overexpress gelsolin. Cunningham, C.C., Stossel, T.P., Kwiatkowski, D.J. Science (1991)
- Activity-induced targeting of profilin and stabilization of dendritic spine morphology. Ackermann, M., Matus, A. Nat. Neurosci. (2003)
- Overexpression of Nd1, a novel Kelch family protein, in the heart of transgenic mice protects against doxorubicin-induced cardiomyopathy. Matsudo, Y., Takamori, Y., Fujimura, L., Nishio, S., Sasagawa, K., Komuro, I., Tokuhisa, T., Hatano, M. Transgenic Res. (2006)
- Profilin I is essential for cell survival and cell division in early mouse development. Witke, W., Sutherland, J.D., Sharpe, A., Arai, M., Kwiatkowski, D.J. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Accumulation of profilin II at the surface of Listeria is concomitant with the onset of motility and correlates with bacterial speed. Geese, M., Schlüter, K., Rothkegel, M., Jockusch, B.M., Wehland, J., Sechi, A.S. J. Cell. Sci. (2000)
- The mouse mammary gland requires the actin-binding protein gelsolin for proper ductal morphogenesis. Crowley, M.R., Head, K.L., Kwiatkowski, D.J., Asch, H.L., Asch, B.B. Dev. Biol. (2000)
- Entorhinal deafferentation induces the expression of profilin mRNA in the reactive microglial cells in the hippocampus. Dong, J.H., Ying, G.X., Zhou, C.F. Glia (2004)
- The actin-binding protein profilin I is localized at synaptic sites in an activity-regulated manner. Neuhoff, H., Sassoè-Pognetto, M., Panzanelli, P., Maas, C., Witke, W., Kneussel, M. Eur. J. Neurosci. (2005)
- The actin-binding protein UNC-115/abLIM controls formation of lamellipodia and filopodia and neuronal morphogenesis in Caenorhabditis elegans. Yang, Y., Lundquist, E.A. Mol. Cell. Biol. (2005)
- Upregulation of cortactin expression during the maturation of megakaryocytes. Zhan, X., Haudenschild, C.C., Ni, Y., Smith, E., Huang, C. Blood (1997)
- Differential phospholipase D activation by bradykinin and sphingosine 1-phosphate in NIH 3T3 fibroblasts overexpressing gelsolin. Banno, Y., Fujita, H., Ono, Y., Nakashima, S., Ito, Y., Kuzumaki, N., Nozawa, Y. J. Biol. Chem. (1999)
- Functional characterization of green fluorescent protein-profilin fusion proteins. Wittenmayer, N., Rothkegel, M., Jockusch, B.M., Schlüter, K. Eur. J. Biochem. (2000)
- Molecular and structural analysis of a continuous birch profilin epitope defined by a monoclonal antibody. Wiedemann, P., Giehl, K., Almo, S.C., Fedorov, A.A., Girvin, M., Steinberger, P., Rüdiger, M., Ortner, M., Sippl, M., Dolecek, C., Kraft, D., Jockusch, B., Valenta, R. J. Biol. Chem. (1996)
- Mena is required for neurulation and commissure formation. Lanier, L.M., Gates, M.A., Witke, W., Menzies, A.S., Wehman, A.M., Macklis, J.D., Kwiatkowski, D., Soriano, P., Gertler, F.B. Neuron (1999)
- A role for complexes of survival of motor neurons (SMN) protein with gemins and profilin in neurite-like cytoplasmic extensions of cultured nerve cells. Sharma, A., Lambrechts, A., Hao, l.e. .T., Le, T.T., Sewry, C.A., Ampe, C., Burghes, A.H., Morris, G.E. Exp. Cell Res. (2005)
- Localization of profilin-1 (Pfn1) and a related sequence (Pfn1-rs) to mouse chromosomes 11 and 15 respectively. Klingenspor, M., Bodnar, J., Xia, Y.R., Welch, C., Lusis, A.J., Reue, K. Mamm. Genome (1997)
- Purification and expression of gCap39. An intracellular and secreted Ca2(+)-dependent actin-binding protein enriched in mononuclear phagocytes. Johnston, P.A., Yu, F.X., Reynolds, G.A., Yin, H.L., Moomaw, C.R., Slaughter, C.A., Südhof, T.C. J. Biol. Chem. (1990)
- Neutrophils lacking platelet-endothelial cell adhesion molecule-1 exhibit loss of directionality and motility in CXCR2-mediated chemotaxis. Wu, Y., Stabach, P., Michaud, M., Madri, J.A. J. Immunol. (2005)
- Properties of tree and grass pollen allergens: reinvestigation of the linkage between solubility and allergenicity. Vrtala, S., Grote, M., Duchêne, M., van Ree, R., Kraft, D., Scheiner, O., Valenta, R. Int. Arch. Allergy Immunol. (1993)
- Profilin gene expression and regulation in a temperature-sensitive breast cancer cell line: tsFT101. Cao, Y., Motomura, K., Ohtsuru, A., Matsumoto, T., Yamashita, S., Kosaka, M. Pflugers Arch. (1997)
- Production and characterization of profilin monoclonal antibodies. Arilla, M.C., Asturias, J.A., Gómez-Bayón, N., Martínez, A., Martínez, J., Palacios, R. Allergologia et immunopathologia. (1997)