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Gene Review

Fbrs  -  fibrosin

Mus musculus

Synonyms: Fbs, Fbs1
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Disease relevance of Fbs1


High impact information on Fbs1

  • Although the expression of Fbs1 was restricted to the adult brain and testis, the Fbs2 transcript was widely expressed [2].
  • Given that Fbs proteins interact with innermost chitobiose in N-glycans, we propose that Fbs proteins distinguish native from unfolded glycoproteins by sensing the exposed chitobiose structure [3].
  • In addition, administration of fibrosin in a wound healing model in mice stimulates increased numbers of myofibroblasts 7days after injury, when compared with untreated, or, control, wounded mice [4].
  • Our observations suggest that fibrosin enhances wound healing and may be involved in accelerating epithelialization, collagen matrix formation, and also remodeling of the extracellular matrix in vivo [5].

Analytical, diagnostic and therapeutic context of Fbs1


  1. A quantitative assay to detect circulating fibrosin and its application in experimental schistosomiasis. Wyler, D.J., Talebian, P. Am. J. Trop. Med. Hyg. (1997) [Pubmed]
  2. Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains. Yoshida, Y., Tokunaga, F., Chiba, T., Iwai, K., Tanaka, K., Tai, T. J. Biol. Chem. (2003) [Pubmed]
  3. Glycoprotein-specific ubiquitin ligases recognize N-glycans in unfolded substrates. Yoshida, Y., Adachi, E., Fukiya, K., Iwai, K., Tanaka, K. EMBO Rep. (2005) [Pubmed]
  4. Fibrosin, a novel fibrogenic cytokine, modulates expression of myofibroblasts. Prakash, S., Paul, W.E., Robbins, P.W. Exp. Mol. Pathol. (2007) [Pubmed]
  5. Fibrosin: a novel lymphokine in wound healing. Prakash, S., Robbins, P.W. Exp. Mol. Pathol. (2001) [Pubmed]
  6. Group B streptococcal surface proteins as targets for protective antibodies: identification of two novel proteins in strains of serotype V. Areschoug, T., Stålhammar-Carlemalm, M., Larsson, C., Lindahl, G. Infect. Immun. (1999) [Pubmed]
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