Disease relevance of Fbs1

• A quantitative assay to detect circulating fibrosin and its application in experimental schistosomiasis [1].
• A novel fibroblast growth factor, fibrosin, was identified as a product of a subpopulation of CD4+ lymphocytes resident in the hepatic egg granulomas [1].

High impact information on Fbs1

• Although the expression of Fbs1 was restricted to the adult brain and testis, the Fbs2 transcript was widely expressed [2].
• Given that Fbs proteins interact with innermost chitobiose in N-glycans, we propose that Fbs proteins distinguish native from unfolded glycoproteins by sensing the exposed chitobiose structure [3].
• In addition, administration of fibrosin in a wound healing model in mice stimulates increased numbers of myofibroblasts 7days after injury, when compared with untreated, or, control, wounded mice [4].
• Our observations suggest that fibrosin enhances wound healing and may be involved in accelerating epithelialization, collagen matrix formation, and also remodeling of the extracellular matrix in vivo [5].

Analytical, diagnostic and therapeutic context of Fbs1

• Importantly, passive and active immunization experiments with mice showed that the Fbs and Rib-like proteins are targets for protective antibodies [6].
• We describe a sensitive, quantitative, antigen-capture enzyme-linked immunosorbent assay that can detect fibrosin in mouse serum and plasma at concentrations > 0.05 pg/ml [1].

References