High impact information on Fgf13

• During hair follicle morphogenesis in newborn mice, FGF-13 protein was first detected in the bulge region and basal layer keratinocytes 3 d after birth [1].
• Using real-time PCR, we found that expression of FGF-13 mRNA is comparable to, or higher than, that of other FGF known to regulate hair growth and wound healing [1].
• Fgf12 and fgf13 [2].
• Murine FGF-12 and FGF-13: expression in embryonic nervous system, connective tissue and heart [2].
• RNAs were detected in developing central nervous system in cells outside the proliferating ependymal layer, and fgf13 RNA was also found throughout the peripheral nervous system [2].

Biological context of Fgf13

• Like their highly conserved human counterparts, murine FGF-12 and FGF-13 are part of a distinct subfamily of FGF-like proteins characterized by a greater degree of amino acid sequence cross-homology and by conserved N-terminal domains which do not include secretion signal sequences [2].

Analytical, diagnostic and therapeutic context of Fgf13

• To gain additional insight into the function of FGF-13, we evaluated its distribution using in situ hybridization and immunohistochemical staining [1].

References