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Gene Review

FGF13  -  fibroblast growth factor 13

Homo sapiens

Synonyms: FGF-13, FGF2, FHF-2, FHF2, Fibroblast growth factor 13, ...
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Disease relevance of FGF13


Psychiatry related information on FGF13


High impact information on FGF13


Chemical compound and disease context of FGF13

  • To investigate the potential regulation of FGF-2 mitogenic activity by heparan sulfate proteoglycans (HSPG), we have treated human breast cancer cells by glycosaminoglycan degrading enzymes or a metabolic inhibitor of proteoglycan sulfation: sodium chlorate [3].
  • We previously reported that FGF-1, FGF-2, and heparin are each capable of stimulating megakaryocytopoiesis in vitro and that heparin has a thrombopoietic effect when administered to patients with chronic immune thrombocytopenic purpura [9].
  • Human endometrial adenocarcinoma HEC-1-B-derived Tet-FGF-2 cells that express FGF-2 under the control of the tetracycline-responsive promoter (Tet-off system) were further transfected with a VEGF(121) anti-sense (AS-VEGF) cDNA [10].
  • These results provide novel finding that ET-AR in PASMCs in vitro is unresponsive to hypoxia per se but is robustly simulated by tyrosine kinase receptor-associated growth factors (FGF-1, FGF-2, PDGF-BB) that themselves are stimulated by hypoxia in lung [11].
  • Alliin significantly inhibited both FGF2 and VEGF secretion from human fibrosarcoma cells in a concentration-dependent manner [12].

Biological context of FGF13


Anatomical context of FGF13


Associations of FGF13 with chemical compounds

  • Consistent with a role for FHFs as signaling molecules, FHF2 isolated from rat brain is serine/threonine-phosphorylated, and FHF can serve as a substrate for p38delta in vitro [17].
  • Oncogenic Ras-induced proliferation is abolished by addition of an anti-FGF-2 blocking antibody, suramin, or treatment with either sodium chlorate or heparitinase, demonstrating an autocrine requirement for FGF-2 [8].
  • Cell-surface heparan sulfate proteoglycans are essential components of the unconventional export machinery of FGF-2 [18].
  • Although fibroblast growth factor 1 (FGF-1) (formerly known as acidic FGF) but not FGF-2 (or basic FGF), has been suggested to play a pathophysiological role in liver regeneration, its clinical application has been restricted by its limited mitogenecity and heparin dependence [19].
  • We found that low concentrations of the specific Hsp90 inhibitors, geldanamycin and radicicol, completely blocked the translocation of FGF-1 and FGF-2 to the cytosol and the nucleus [20].

Physical interactions of FGF13

  • FHF2 also binds weakly to IB2(Delta1-436) and can thereby increase p38delta interaction with IB2(Delta1-436) [17].

Regulatory relationships of FGF13

  • In proliferation studies with BaF3 cells, FGF-13 preferentially activates cell clones expressing either FGF receptor variant, 3-IIIc or 4 [21].

Other interactions of FGF13

  • FGF-13 is most homologous, 70% similarity at the amino acid level, to FGF-8 [21].
  • 1. The SLC9A6 and FGF13 genes in this region, were selected and screened for mutation in this family, but no mutation was detected [22].
  • Recently, it has been shown that cells residing in the sub-ventricular zone of adult brains have characteristics of neuronal precursors: they can respond to FGF-2 by proliferation and FGF-1 induces neuronal differentiation [23].

Analytical, diagnostic and therapeutic context of FGF13

  • Through a combination of matrix-assisted laser desorption ionization mass spectrometry and chemical crosslinking, we show here that, under identical conditions, FGF-1 and FGF-2 differ in the degree and kind of oligomerization [16].
  • Polyclonal primary antibodies (Dr. A. Baird, Whittier Institute, La Jolla, CA) to FGF-1 and FGF-2 and fluorescein-conjugated secondary antibodies were used with confocal microscopy to allow quantitation and subcellular localization of the antigens [24].
  • The interaction between FGF-2 and proteoglycans was assayed by examining the binding of 125I-FGF-2 to breast cancer cell cultures as well as to cationic membranes loaded with HSPG [3].
  • A novel ELISA based method was developed to detect solubilisation of FGF-2 following addition of heparin and heparitinase to bronchial tissue slices [25].
  • A potent fibroproliferative factor in bronchoalveolar lavage fluid in asthma is fibroblast growth factor-2 (FGF-2) [25].


  1. Fibroblast growth factor homologous factor 2 (FHF2): gene structure, expression and mapping to the Börjeson-Forssman-Lehmann syndrome region in Xq26 delineated by a duplication breakpoint in a BFLS-like patient. Gecz, J., Baker, E., Donnelly, A., Ming, J.E., McDonald-McGinn, D.M., Spinner, N.B., Zackai, E.H., Sutherland, G.R., Mulley, J.C. Hum. Genet. (1999) [Pubmed]
  2. Fibroblast growth factor 1 and fibroblast growth factor 2 immunoreactivity in gastrointestinal tumours. el-Hariry, I., Pignatelli, M., Lemoine, N. J. Pathol. (1997) [Pubmed]
  3. Heparan sulfate proteoglycans play a dual role in regulating fibroblast growth factor-2 mitogenic activity in human breast cancer cells. Delehedde, M., Deudon, E., Boilly, B., Hondermarck, H. Exp. Cell Res. (1996) [Pubmed]
  4. Heparin octasaccharides inhibit angiogenesis in vivo. Hasan, J., Shnyder, S.D., Clamp, A.R., McGown, A.T., Bicknell, R., Presta, M., Bibby, M., Double, J., Craig, S., Leeming, D., Stevenson, K., Gallagher, J.T., Jayson, G.C. Clin. Cancer Res. (2005) [Pubmed]
  5. Hippocampal FGF-2 and FGFR1 mRNA expression in major depression, schizophrenia and bipolar disorder. Gaughran, F., Payne, J., Sedgwick, P.M., Cotter, D., Berry, M. Brain Res. Bull. (2006) [Pubmed]
  6. Antiangiogenic activity of prostate-specific antigen. Fortier, A.H., Nelson, B.J., Grella, D.K., Holaday, J.W. J. Natl. Cancer Inst. (1999) [Pubmed]
  7. FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2. Pardo, O.E., Wellbrock, C., Khanzada, U.K., Aubert, M., Arozarena, I., Davidson, S., Bowen, F., Parker, P.J., Filonenko, V.V., Gout, I.T., Sebire, N., Marais, R., Downward, J., Seckl, M.J. EMBO J. (2006) [Pubmed]
  8. Oncogenic Ras-induced proliferation requires autocrine fibroblast growth factor 2 signaling in skeletal muscle cells. Fedorov, Y.V., Rosenthal, R.S., Olwin, B.B. J. Cell Biol. (2001) [Pubmed]
  9. Enhanced growth of megakaryocyte colonies in culture in the presence of heparin and fibroblast growth factor. Chen, Q.S., Wang, Z.Y., Han, Z.C. Int. J. Hematol. (1999) [Pubmed]
  10. Distinct role of fibroblast growth factor-2 and vascular endothelial growth factor on tumor growth and angiogenesis. Giavazzi, R., Sennino, B., Coltrini, D., Garofalo, A., Dossi, R., Ronca, R., Tosatti, M.P., Presta, M. Am. J. Pathol. (2003) [Pubmed]
  11. Fibroblast growth factor mediates hypoxia-induced endothelin-- a receptor expression in lung artery smooth muscle cells. Li, P., Oparil, S., Sun, J.Z., Thompson, J.A., Chen, Y.F. J. Appl. Physiol. (2003) [Pubmed]
  12. Anti-angiogenesis efficacy of the garlic ingredient alliin and antioxidants: role of nitric oxide and p53. Mousa, A.S., Mousa, S.A. Nutrition and cancer. (2005) [Pubmed]
  13. Assignment of FGF13 to human chromosome band Xq21 by in situ hybridization. Lovec, H., Hartung, H., Verdier, A.S., Mattéi, M.G., Birnbaum, D., Goldfarb, M., Coulier, F. Cytogenet. Cell Genet. (1997) [Pubmed]
  14. Integration of endothelial cells in multicellular spheroids prevents apoptosis and induces differentiation. Korff, T., Augustin, H.G. J. Cell Biol. (1998) [Pubmed]
  15. Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier of dorsal root axons. Wittmack, E.K., Rush, A.M., Craner, M.J., Goldfarb, M., Waxman, S.G., Dib-Hajj, S.D. J. Neurosci. (2004) [Pubmed]
  16. Fibroblast growth factors 1 and 2 are distinct in oligomerization in the presence of heparin-like glycosaminoglycans. Venkataraman, G., Shriver, Z., Davis, J.C., Sasisekharan, R. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  17. Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase. Schoorlemmer, J., Goldfarb, M. J. Biol. Chem. (2002) [Pubmed]
  18. Cell-surface heparan sulfate proteoglycans are essential components of the unconventional export machinery of FGF-2. Zehe, C., Engling, A., Wegehingel, S., Sch??fer, T., Nickel, W. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  19. A novel chimeric fibroblast growth factor for liver parenchymal cells. Imamura, T., Tanahashi, T. Hepatology (1996) [Pubmed]
  20. FGF-1 and FGF-2 Require the Cytosolic Chaperone Hsp90 for Translocation into the Cytosol and the Cell Nucleus. Wesche, J., Malecki, J., Wiedlocha, A., Skjerpen, C.S., Claus, P., Olsnes, S. J. Biol. Chem. (2006) [Pubmed]
  21. Identification and characterization of a novel member of the fibroblast growth factor family. Greene, J.M., Li, Y.L., Yourey, P.A., Gruber, J., Carter, K.C., Shell, B.K., Dillon, P.A., Florence, C., Duan, D.R., Blunt, A., Ornitz, D.M., Ruben, S.M., Alderson, R.F. Eur. J. Neurosci. (1998) [Pubmed]
  22. Confirmation and refinement of a genetic locus of congenital motor nystagmus in Xq26.3-q27.1 in a Chinese family. Zhang, B., Xia, K., Ding, M., Liang, D., Liu, Z., Pan, Q., Hu, Z., Wu, L.Q., Cai, F., Xia, J. Hum. Genet. (2005) [Pubmed]
  23. Regulation of neurogenesis in the embryonic and adult brain by fibroblast growth factors. Bartlett, P.F., Dutton, R., Likiardopoulos, V., Brooker, G. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. (1994) [Pubmed]
  24. Expression of fibroblast growth factors in thyroid cancer. Eggo, M.C., Hopkins, J.M., Franklyn, J.A., Johnson, G.D., Sanders, D.S., Sheppard, M.C. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  25. Epithelial expression and release of FGF-2 from heparan sulphate binding sites in bronchial tissue in asthma. Shute, J.K., Solic, N., Shimizu, J., McConnell, W., Redington, A.E., Howarth, P.H. Thorax (2004) [Pubmed]
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