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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Gdi2  -  guanosine diphosphate (GDP) dissociation...

Mus musculus

Synonyms: GDI beta, GDI-2, GDI-3, GDI-B, GDIB, ...
 
 
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High impact information on Gdi2

  • The degree of deduced amino acid sequence identity between mouse GDI-2 and our mouse GDI-1 cDNA clone is 86% [1].
  • Here we report the isolation of a full-length cDNA encoding a novel GDI isoform of 445 amino acids (GDI-2) with a deduced molecular weight of 50,649 from mouse skeletal muscle [1].
  • Differentiation of 3T3-L1 fibroblasts into highly insulin-responsive adipocytes was accompanied by large increases in both mRNA and protein levels of GDI-1 and GDI-2 [1].
  • Northern blot analysis revealed that hu GDI alpha gene is expressed abundantly in the brain but much less in other tissues, while hu GDI beta gene is ubiquitously expressed [2].
  • We show that GDI-3 is able to inhibit GDP/GTP exchange of RhoB and to release GDP-bound but not GTP-bound RhoB from cell membranes [3].
 

Anatomical context of Gdi2

  • We also show that the proportion of Rab proteins complexed with either isoform depends on the relative abundance of Rab3A GDI and GDI beta in the cytosol [4].

References

  1. Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle. Shisheva, A., Südhof, T.C., Czech, M.P. Mol. Cell. Biol. (1994) [Pubmed]
  2. Cloning of a brain-type isoform of human Rab GDI and its expression in human neuroblastoma cell lines and tumor specimens. Nishimura, N., Goji, J., Nakamura, H., Orita, S., Takai, Y., Sano, K. Cancer Res. (1995) [Pubmed]
  3. RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG. Zalcman, G., Closson, V., Camonis, J., Honoré, N., Rousseau-Merck, M.F., Tavitian, A., Olofsson, B. J. Biol. Chem. (1996) [Pubmed]
  4. Rab proteins form in vivo complexes with two isoforms of the GDP-dissociation inhibitor protein (GDI). Yang, C., Slepnev, V.I., Goud, B. J. Biol. Chem. (1994) [Pubmed]
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