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Gdi1  -  guanosine diphosphate (GDP) dissociation...

Mus musculus

Synonyms: GDI-1, GDIA, GDIalpha, Guanosine diphosphate dissociation inhibitor 1, Rab GDI alpha, ...
 
 
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Disease relevance of Gdi1

 

Psychiatry related information on Gdi1

  • Mice deficient for the synaptic vesicle protein Rab3a show impaired spatial reversal learning and increased explorative activity but none of the behavioral changes shown by mice deficient for the Rab3a regulator Gdi1 [3].
  • The general similarity to human mental retardation is striking, and suggests that the Gdi1 mutants may provide insights into the human defect and into the molecular mechanisms important for development of cognitive functions [4].
  • Gdi1-deficient mice are impaired in tasks requiring formation of short-term temporal associations, suggesting a defect in short-term memory [4].
  • Deletion of the mental retardation gene Gdi1 impairs associative memory and alters social behavior in mice [4].
 

High impact information on Gdi1

 

Biological context of Gdi1

 

Anatomical context of Gdi1

  • It has been recently recognized that at least two GDP dissociation inhibitor (GDI) isoforms, GDI-1 and GDI-2, can bind and release GDP-bound Rab proteins from membranes (Shisheva, A., Südhof, T.C., and Czech, M. P. (1994) Mol. Cell. Biol. 14, 3459-3468) [7].
  • The present studies show that a strikingly higher level of GDI-2 fractionates with total membranes of COS-1 cells, Chinese hamster ovary cells, and 3T3-L1 adipocytes compared to GDI-1, which is virtually totally cytosolic [7].
  • Previous work showed strikingly higher levels of GDI-2 than GDI-1 fractionate with total membranes of cultured cells and are visualized in the perinuclear region in 3T3-L1 adipocytes [8].
 

Regulatory relationships of Gdi1

  • The goals of this study were to analyse possible behavioral consequences of the lack of synaptic plasticity in the mossy fiber pathway using a broad battery of sensitive behavioral measures that has been used previously to analyse the behavior of Gdi1 mice lacking a protein thought to regulate Rab3a [3].
 

Other interactions of Gdi1

  • On the other hand, the phenotypic changes in the Rab3a(-/-) mice bore no relation to the behavioral changes as observed in the Gdi1 mice [3].

References

  1. Role of rab GDP dissociation inhibitor alpha in regulating plasticity of hippocampal neurotransmission. Ishizaki, H., Miyoshi, J., Kamiya, H., Togawa, A., Tanaka, M., Sasaki, T., Endo, K., Mizoguchi, A., Ozawa, S., Takai, Y. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  2. Cloning of a brain-type isoform of human Rab GDI and its expression in human neuroblastoma cell lines and tumor specimens. Nishimura, N., Goji, J., Nakamura, H., Orita, S., Takai, Y., Sano, K. Cancer Res. (1995) [Pubmed]
  3. Mice deficient for the synaptic vesicle protein Rab3a show impaired spatial reversal learning and increased explorative activity but none of the behavioral changes shown by mice deficient for the Rab3a regulator Gdi1. D'Adamo, P., Wolfer, D.P., Kopp, C., Tobler, I., Toniolo, D., Lipp, H.P. Eur. J. Neurosci. (2004) [Pubmed]
  4. Deletion of the mental retardation gene Gdi1 impairs associative memory and alters social behavior in mice. D'Adamo, P., Welzl, H., Papadimitriou, S., Raffaele di Barletta, M., Tiveron, C., Tatangelo, L., Pozzi, L., Chapman, P.F., Knevett, S.G., Ramsay, M.F., Valtorta, F., Leoni, C., Menegon, A., Wolfer, D.P., Lipp, H.P., Toniolo, D. Hum. Mol. Genet. (2002) [Pubmed]
  5. Targeted disruption of guanosine diphosphate-dissociation inhibitor for Rho-related proteins, GDID4: normal hematopoietic differentiation but subtle defect in superoxide production by macrophages derived from in vitro embryonal stem cell differentiation. Guillemot, J.C., Kruskal, B.A., Adra, C.N., Zhu, S., Ko, J.L., Burch, P., Nocka, K., Seetoo, K., Simons, E., Lim, B. Blood (1996) [Pubmed]
  6. Midlatency auditory event-related potentials in mice: comparison to midlatency auditory ERPs in humans. Umbricht, D., Vyssotky, D., Latanov, A., Nitsch, R., Brambilla, R., D'Adamo, P., Lipp, H.P. Brain Res. (2004) [Pubmed]
  7. Differential intracellular localizations of GDP dissociation inhibitor isoforms. Insulin-dependent redistribution of GDP dissociation inhibitor-2 in 3T3-L1 adipocytes. Shisheva, A., Buxton, J., Czech, M.P. J. Biol. Chem. (1994) [Pubmed]
  8. Pericentriolar targeting of GDP-dissociation inhibitor isoform 2. Shisheva, A., Doxsey, S.J., Buxton, J.M., Czech, M.P. Eur. J. Cell Biol. (1995) [Pubmed]
 
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