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Gene Review

Gnal  -  guanine nucleotide binding protein, alpha...

Mus musculus

Synonyms: 2610011C15Rik, 9630020G10Rik, AI843190, Adenylate cyclase-stimulating G alpha protein, olfactory type, G alpha 10, ...
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High impact information on Gnal

  • As measured by Western blotting, the striatal stimulatory G proteins Gs and Golf were reduced by 20% and 25% at 10 days following cessation of MPTP treatment, despite a significant impairment in striatal dopamine levels (<90% reduction) [1].
  • RT-PCR confirmed the presence of Golf in DRG and in situ hybridization studies localised this molecule to primary sensory neurons [2].
  • Following UNO, ACIII but not Golf -IR levels diverged comparing the occluded to the non-occluded sides of the nasal cavity [3].


  1. Differential regulation of striatal G protein levels following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration in C57 BL/6 mice. Marcotte, E.R., Chugh, A., Barlas, C., Mishra, R.K. Neurosci. Lett. (2001) [Pubmed]
  2. Molecular localisation of a G-protein mRNA using differential display and in situ hybridization. Wilkinson, R., Tscharke, D., Simmons, A. Brain Res. Brain Res. Protoc. (2000) [Pubmed]
  3. Naris occlusion alters transductory protein immunoreactivity in olfactory epithelium. Coppola, D.M., Waguespack, A.M., Reems, M.R., Butman, M.L., Cherry, J.A. Histol. Histopathol. (2006) [Pubmed]
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