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Gene Review

Gzmd  -  granzyme D

Mus musculus

Synonyms: CCP5, Ctla-5, Ctla5, Granzyme D
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Disease relevance of Gzmd

  • Stromal lines supported growth of a pre-T lymphoma clone BTK at an efficiency proportional to the expression level of granzyme D, while a stromal line lacking granzyme D failed to do so [1].

High impact information on Gzmd


  1. Selective expression and function of granzyme D in lymphohematopoietic stromal cells. Yokoi, A., Kina, T., Minato, N. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  2. A family of serine esterases in lytic granules of cytolytic T lymphocytes. Masson, D., Tschopp, J. Cell (1987) [Pubmed]
  3. Structure and evolution of the cytotoxic cell proteinase genes CCP3, CCP4 and CCP5. Prendergast, J.A., Pinkoski, M., Wolfenden, A., Bleackley, R.C. J. Mol. Biol. (1991) [Pubmed]
  4. Peritoneal exudate lymphocyte and mixed lymphocyte culture hybridomas are cytolytic in the absence of cytotoxic cell proteinases and perforin. Helgason, C.D., Prendergast, J.A., Berke, G., Bleackley, R.C. Eur. J. Immunol. (1992) [Pubmed]
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