Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Gzmd - granzyme D

Mus musculus

Synonyms: CCP5, Ctla-5, Ctla5, Granzyme D

Helgason, C.D. et al., Yokoi, A. et al., Masson, D. et al., Prendergast, J.A. et al.

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Disease relevance of Gzmd

Stromal lines supported growth of a pre-T lymphoma clone BTK at an efficiency proportional to the expression level of granzyme D, while a stromal line lacking granzyme D failed to do so [1].

High impact information on Gzmd

Antibodies raised against granzyme B strongly cross-react with A, G, and H, and antibodies to granzyme D recognize C, E, and F. These antigenic relationships correlate with similarities in the N-terminal amino acid sequences [2].
Structure and evolution of the cytotoxic cell proteinase genes CCP3, CCP4 and CCP5 [3].
We have utilized the sensitive polymerase chain reaction (PCR) to determine whether cytotoxic T lymphocyte (CTL) hybridomas generated from peritoneal exudate lymphocytes (PEL) and mixed lymphocyte cultures (MLC) express transcripts for perforin and the cytotoxic cell proteinases CCP1 to CCP5 [4].
Selective expression and function of granzyme D in lymphohematopoietic stromal cells [1].

References

Selective expression and function of granzyme D in lymphohematopoietic stromal cells. Yokoi, A., Kina, T., Minato, N. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
A family of serine esterases in lytic granules of cytolytic T lymphocytes. Masson, D., Tschopp, J. Cell (1987) [Pubmed]
Structure and evolution of the cytotoxic cell proteinase genes CCP3, CCP4 and CCP5. Prendergast, J.A., Pinkoski, M., Wolfenden, A., Bleackley, R.C. J. Mol. Biol. (1991) [Pubmed]
Peritoneal exudate lymphocyte and mixed lymphocyte culture hybridomas are cytolytic in the absence of cytotoxic cell proteinases and perforin. Helgason, C.D., Prendergast, J.A., Berke, G., Bleackley, R.C. Eur. J. Immunol. (1992) [Pubmed]

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