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Gene Review

Gzmf  -  granzyme F

Mus musculus

Synonyms: C134, CCP4, CTL serine protease 3, Ccp4, Ctla-7, ...
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High impact information on Gzmf


Anatomical context of Gzmf

  • In contrast to the murine granzymes A to E and G, granzyme F is exclusively expressed in the CD4-CD8+ subset of peripheral T cells [2].

Associations of Gzmf with chemical compounds


Other interactions of Gzmf

  • The putative mature proteins of MCSP-2 and MCSP-3 are each composed of 228 amino acids with molecular weights of 25,477 and 25,360, respectively [1].
  • Structure and evolution of the cytotoxic cell proteinase genes CCP3, CCP4 and CCP5 [3].
  • Three proteins with inhibitory activity were thus purified, the serine esterase MCSP-3/granzyme F and the histones H2B and H3 [4].


  1. Isolation and sequence analysis of serine protease cDNAs from mouse cytolytic T lymphocytes. Kwon, B.S., Kestler, D., Lee, E., Wakulchik, M., Young, J.D. J. Exp. Med. (1988) [Pubmed]
  2. Genomic organization and subchromosomal in situ localization of the murine granzyme F, a serine protease expressed in CD8+ T cells. Jenne, D.E., Zimmer, M., Garcia-Sanz, J.A., Tschopp, J., Lichter, P. J. Immunol. (1991) [Pubmed]
  3. Structure and evolution of the cytotoxic cell proteinase genes CCP3, CCP4 and CCP5. Prendergast, J.A., Pinkoski, M., Wolfenden, A., Bleackley, R.C. J. Mol. Biol. (1991) [Pubmed]
  4. Plasma membrane-associated proteins with the ability to partially inhibit perforin-mediated lysis. Ojcius, D.M., Muller, S., Hasselkus-Light, C.S., Young, J.D., Jiang, S. Immunol. Lett. (1991) [Pubmed]
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