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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

FAM84A  -  family with sequence similarity 84, member A

Homo sapiens

Synonyms: FLJ35392, NSE1, Neurologic sensory protein 1, PP11517, Protein FAM84A
 
 
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Disease relevance of FAM84A

  • A gene encoding a family with sequence similarity 84, member A (FAM84A) enhanced migration of human colon cancer cells [1].
 

High impact information on FAM84A

  • Our results indicate a possibility that up-regulation of FAM84A plays a critical role in progression of colon cancer [1].
  • In addition, we found that exogenous FAM84A expression increased cell motility in NIH3T3 cells, and that phosphorylation of serine 38 of FAM84A was associated with morphology of cells [1].
  • One of these was a gene termed FAM84A that was not expressed in any of the 23 normal tissues examined except the testis [1].
  • On the contrary, NSE1 and GAS mRNAs were not detected either in patient or in control blood samples; however, they were abundantly expressed in normal and cancerous colon mucosa, encouraging further search for useful markers able to detect epithelial cells in peripheral blood [2].

References

  1. A gene encoding a family with sequence similarity 84, member A (FAM84A) enhanced migration of human colon cancer cells. Kobayashi, T., Masaki, T., Sugiyama, M., Atomi, Y., Furukawa, Y., Nakamura, Y. Int. J. Oncol. (2006) [Pubmed]
  2. Search for epithelial-specific mRNAs in peripheral blood of patients with colon cancer by RT-PCR. Solmi, R., De Sanctis, P., Zucchini, C., Ugolini, G., Rosati, G., Del Governatore, M., Coppola, D., Yeatman, T.J., Lenzi, L., Caira, A., Zanotti, S., Taffurelli, M., Carinci, P., Valvassori, L., Strippoli, P. Int. J. Oncol. (2004) [Pubmed]
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