The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SLC36A2  -  solute carrier family 36 (proton/amino...

Homo sapiens

Synonyms: PAT2, Proton-coupled amino acid transporter 2, Proton/amino acid transporter 2, Solute carrier family 36 member 2, TRAMD1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SLC36A2


High impact information on SLC36A2

  • The chromosomal mutants PRO1 and PAT2 contain a single wild beet minichromosome with centromere activity and provide, together with cloned centromeric DNA sequences, an experimental system toward the molecular isolation of individual plant centromeres [2].
  • RESULTS: Both PAT1 and PAT2 bind to and condense DNA into small particles as shown by laser scattering techniques [3].
  • Gene delivery by PAT2/DNA complexes is chloroquine-dependent, can be blocked completely by free ligand (CSIPPEVKFNKPFVFLI), and is highly efficient (e.g. approximately five-fold more effective than lipofectamine) [3].
  • Like glyceraldehyde-3-phosphate dehydrogenase, the beta-tubulin amino acid sequence was identical in all Phaeosphaeria species used in this study, with the exception of the two Pat2 isolates [4].
  • Prespecified pattern 1 was identified in 81%, PAT 2 in 8%, and PAT 3 in 11% of the patients [5].

Biological context of SLC36A2


Anatomical context of SLC36A2

  • The human PAT1 and PAT2 transporters when functionally expressed in Xenopus laevis oocytes show characteristics similar to those of their mouse counterparts [7].

Other interactions of SLC36A2

  • We recently cloned and functionally characterized two novel proton/amino acid transporters (PAT1 and PAT2) from mouse [7].

Analytical, diagnostic and therapeutic context of SLC36A2

  • Perfusion: Time-resolved 3D GRE pulse sequence (FLASH, TE/TR/alpha: 0.8/1.9 ms/40 degrees ), parallel imaging (GRAPPA, PAT 2) [8].


  1. Organization and expression of the SLC36 cluster of amino acid transporter genes. Bermingham, J.R., Pennington, J. Mamm. Genome (2004) [Pubmed]
  2. The large-scale organization of the centromeric region in Beta species. Gindullis, F., Desel, C., Galasso, I., Schmidt, T. Genome Res. (2001) [Pubmed]
  3. A small, synthetic peptide for gene delivery via the serpin-enzyme complex receptor. Patel, S., Zhang, X., Collins, L., Fabre, J.W. The journal of gene medicine. (2001) [Pubmed]
  4. Sequence diversity of beta-tubulin (tubA) gene in Phaeosphaeria nodorum and P. avenaria. Malkus, A., Reszka, E., Chang, C.J., Arseniuk, E., Chang, P.F., Ueng, P.P. FEMS Microbiol. Lett. (2005) [Pubmed]
  5. Basic components and patterns of acute ischemia recovery assessed from continuous ST monitoring in acute myocardial infarction treated by thrombolytic therapy. Col, J., Pirenne, B., Decoster, O., Payen, B., Deligne, B., Purnode, P., Renkin, J. Journal of electrocardiology. (1994) [Pubmed]
  6. The SLC36 family: proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis. Boll, M., Daniel, H., Gasnier, B. Pflugers Arch. (2004) [Pubmed]
  7. A cluster of proton/amino acid transporter genes in the human and mouse genomes. Boll, M., Foltz, M., Rubio-Aliaga, I., Daniel, H. Genomics (2003) [Pubmed]
  8. Contrast-enhanced 3D MRI of lung perfusion in children with cystic fibrosis-initial results. Eichinger, M., Puderbach, M., Fink, C., Gahr, J., Ley, S., Plathow, C., Tuengerthal, S., Zuna, I., Müller, F.M., Kauczor, H.U. European radiology. (2006) [Pubmed]
WikiGenes - Universities