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Gene Review

Hnrnpc  -  heterogeneous nuclear ribonucleoprotein C

Mus musculus

Synonyms: AL022939, D14Wsu171e, Heterogeneous nuclear ribonucleoproteins C1/C2, Hnrpc, Hnrpc1, ...
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High impact information on Hnrpc


Biological context of Hnrpc

  • hnRNP C is required for postimplantation mouse development but Is dispensable for cell viability [1].
  • Wild-type hnRNP-C1 and hnRNP-C1 modified at the basal sites of phosphorylation (S247E and S286E) both avidly bound RNA with similar binding constants [2].
  • By using nuclear yellow fluorescent protein (YFP) fusion, we determined that the C-terminal 40-amino-acid region of hnRNP C1/C2 is a novel nuclear export signal responsive to ROCK-activation [3].

Anatomical context of Hnrpc

  • Short interfering RNA-mediated gene-specific knockdown of CUGBP2, GRY-RBP, and hnRNP-C1 resulted in increased editing in Caco-2 cells, consistent with their known inhibitory function [4].

Associations of Hnrpc with chemical compounds


Other interactions of Hnrpc

  • The C-terminal region is more divergent between hnRNP C and Raly [6].
  • Following the variable region, a basic region and a leucine zipper are conserved in all hnRNP C-related proteins including mouse and human Raly [6].

Analytical, diagnostic and therapeutic context of Hnrpc


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