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Gene Review

Igkc  -  immunoglobulin kappa constant

Mus musculus

Synonyms: Ig kappa chain C region, Igk-C
 
 
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High impact information on Igk-C

  • We propose that this tissue-specific enhancer contributes to the activation of somatically rearranged immunoglobulin variable region genes and possibly to abnormal expression of other genes (e.g. c-myc) that become translocated to its domain of influence [1].
  • Based on the distribution of mutations that have been found in expressed immunoglobulin variable-region genes, a model that links the introduction of somatic mutations to DNA replication during the V-J joining event is proposed [2].
  • The map location of this cluster between IgK and Tcrb coincides with the morphological mutation hypodactyly (Hd) [3].
  • Immunoglobulin variable region promoters are predominantly B-cell specific, but the molecular basis for this specificity has not been elucidated [4].
  • A plasmid encoding an IgK leader peptide-driven secretable fusion protein of the active GLP-1 and IgG(1)-Fc was constructed for mammalian expression [5].
 

Biological context of Igk-C

 

Anatomical context of Igk-C

 

Other interactions of Igk-C

  • This is consistent with the constitutive activation of N-myc by a juxtaposition of the IgK and N-myc loci [10].
  • First flow cytometric analysis revealed that surface expression of CD45R, IgM, and IgK by splenocytes from MCMV-infected mice was significantly reduced with a concomitant increase in the frequency of surface IgG-expressing cells [11].
  • Effect of immunoglobulin variable region structure on C3b and C4b deposition [12].
 

Analytical, diagnostic and therapeutic context of Igk-C

References

  1. A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes. Banerji, J., Olson, L., Schaffner, W. Cell (1983) [Pubmed]
  2. Somatic mutation of immunoglobulin light-chain variable-region genes. Selsing, E., Storb, U. Cell (1981) [Pubmed]
  3. Genetic and cytogenetic localisation of the homeo box containing genes on mouse chromosome 6 and human chromosome 7. Bućan, M., Yang-Feng, T., Colberg-Poley, A.M., Wolgemuth, D.J., Guenet, J.L., Francke, U., Lehrach, H. EMBO J. (1986) [Pubmed]
  4. Mouse lymphoid cell line selected to have high immunoglobulin promoter activity. Tantin, D., Sharp, P.A. Mol. Cell. Biol. (2002) [Pubmed]
  5. Gene therapy of diabetes using a novel GLP-1/IgG1-Fc fusion construct normalizes glucose levels in db/db mice. Kumar, M., Hunag, Y., Glinka, Y., Prud'homme, G.J., Wang, Q. Gene Ther. (2007) [Pubmed]
  6. Immunoglobulin constant kappa gene alleles in twelve strains of mice. Solin, M.L., Kaartinen, M. Immunogenetics (1993) [Pubmed]
  7. Assignment of pig immunoglobulin kappa gene IGKC, to chromosome 3q12-q14 by fluorescence in situ hybridization (FISH). Rettenberger, G., Bruch, J., Leeb, T., Brenig, B., Klett, C., Hameister, H. Mamm. Genome (1996) [Pubmed]
  8. Human constant regions influence the antibody binding characteristics of mouse-human chimeric IgG subclasses. McCloskey, N., Turner, M.W., Steffner, P., Owens, R., Goldblatt, D. Immunology (1996) [Pubmed]
  9. Linkage of a 7S RNA sequence and kappa light chain genes in the mouse. Taylor, B.A., Rowe, L., Gibson, D.M., Riblet, R., Yetter, R., Gottlieb, P.D. Immunogenetics (1985) [Pubmed]
  10. An exceptional mouse plasmacytoma with a new kappa/N-myc [T(6; 12) (C1; B)] translocation expresses N-myc but not c-myc. Silva, S., Wang, Y., Babonits, M., Axelson, H., Wiener, F., Klein, G. Curr. Top. Microbiol. Immunol. (1992) [Pubmed]
  11. Murine cytomegalovirus infection-induced polyclonal B cell activation is independent of CD4+ T cells and CD40. Karupiah, G., Sacks, T.E., Klinman, D.M., Fredrickson, T.N., Hartley, J.W., Chen, J.H., Morse, H.C. Virology (1998) [Pubmed]
  12. Effect of immunoglobulin variable region structure on C3b and C4b deposition. White, K.D., Frank, M.B., Foundling, S., Waxman, F.J. Mol. Immunol. (1996) [Pubmed]
 
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