High impact information on Igk-C

• We propose that this tissue-specific enhancer contributes to the activation of somatically rearranged immunoglobulin variable region genes and possibly to abnormal expression of other genes (e.g. c-myc) that become translocated to its domain of influence [1].
• Based on the distribution of mutations that have been found in expressed immunoglobulin variable-region genes, a model that links the introduction of somatic mutations to DNA replication during the V-J joining event is proposed [2].
• The map location of this cluster between IgK and Tcrb coincides with the morphological mutation hypodactyly (Hd) [3].
• Immunoglobulin variable region promoters are predominantly B-cell specific, but the molecular basis for this specificity has not been elucidated [4].
• A plasmid encoding an IgK leader peptide-driven secretable fusion protein of the active GLP-1 and IgG(1)-Fc was constructed for mammalian expression [5].

Biological context of Igk-C

• Mice belonging to the kappa (Igk) haplotype e (SJL) have allele c of the Igk-C gene [6].
• In restriction fragment length polymorphism (RFLP) studies the SJL mouse strain has been shown to belong to a Igk-C allogroup different from other common inbred mouse strains [6].
• Assignment of pig immunoglobulin kappa gene IGKC, to chromosome 3q12-q14 by fluorescence in situ hybridization (FISH) [7].
• Although antibody affinity is primarily determined by immunoglobulin variable region structure human IgG antibodies of the four subclasses specific for the same antigen have been shown to differ in their affinity [8].

Anatomical context of Igk-C

• One such variant, designated Rn7s-6, showed close linkage to the Ly-2,3-Igk-V (T lymphocyte antigens 2 and 3, kappa immunoglobulin variable region) cluster of markers on chromosome 6 [9].

Other interactions of Igk-C

• This is consistent with the constitutive activation of N-myc by a juxtaposition of the IgK and N-myc loci [10].
• First flow cytometric analysis revealed that surface expression of CD45R, IgM, and IgK by splenocytes from MCMV-infected mice was significantly reduced with a concomitant increase in the frequency of surface IgG-expressing cells [11].
• Effect of immunoglobulin variable region structure on C3b and C4b deposition [12].

Analytical, diagnostic and therapeutic context of Igk-C

• Genomic DNA for the immunoglobulin (Ig) constant kappa Igk-C gene region was amplified by the polymerase chain reaction (PCR) method and sequenced from twelve commonly used inbred mouse strains [6].

References