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Gene Review

SPTSSB  -  serine palmitoyltransferase, small subunit B

Homo sapiens

Synonyms: ADMP, C3orf57, Protein ADMP, SSSPTB, Serine palmitoyltransferase small subunit B, ...
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Disease relevance of C3orf57

  • Cloning and characterization of ADMP has made it feasible to determine its prospective role in the absence of androgens in prostate cancer [1].

High impact information on C3orf57

  • Using suppression subtractive hybridization between mRNA derived from prostates of hypogonadal (hpg) with or without 14 days of testosterone replacement we have cloned a novel gene from the hpg prostate, termed ADMP (for androgen down regulated gene expressed in mouse prostate), that is down regulated by androgens [1].
  • Human ADMP expression was seen predominantly in the prostate epithelium with weaker expression in the fibroblasts and endothelial cells [1].
  • Human ADMP mRNA expression is suppressed by androgens in the androgen-sensitive LNCaP cell line [1].
  • During cleavage and gastrula stages, the dorsal and ventral midlines are independently induced by FGF9/16/20 and the BMP ligand ADMP, respectively [2].

Anatomical context of C3orf57

  • ADMP expression is strong in hpg mouse prostate, weak in mature castrated mouse prostate and absent in normal intact or androgen-replaced hpg mouse prostates [1].

Analytical, diagnostic and therapeutic context of C3orf57

  • Other factors proving to be predictors of successful rehabilitation were less pronounced psychopathological symptoms (ADMP), better social functioning (GAS), a higher level of education and an early introduction to work therapy [3].


  1. Molecular cloning and characterization of a novel androgen repressible gene expressed in the prostate epithelium. Singh, J., Young, L., Handelsman, D.J., Dong, Q. Gene (2005) [Pubmed]
  2. Formation of the ascidian epidermal sensory neurons: insights into the origin of the chordate peripheral nervous system. Pasini, A., Amiel, A., Rothb??cher, U., Roure, A., Lemaire, P., Darras, S. PLoS Biol. (2006) [Pubmed]
  3. Work therapy for schizophrenic patients: results of a 3-year prospective study in Germany. Reker, T., Eikelmann, B. European archives of psychiatry and clinical neuroscience. (1997) [Pubmed]
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