Gene Review:
SGMS2 - sphingomyelin synthase 2
Homo sapiens
Synonyms:
MGC26963, Phosphatidylcholine:ceramide cholinephosphotransferase 2, SMS2, Sphingomyelin synthase 2
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High impact information on SGMS2
- Studies by RT-PCR and immunoblotting have shown that the expression of SMS2 was limited to late round spermatids and elongating spermatids, but it was not detected in late elongate spermatids and Sertoli cells [1].
- Using the technique of subtraction hybridization, we have isolated a full-length cDNA encoding SMS2 from rat testes, which shared 93 and 87% identity at the nucleotide level with SMS2 in mice and humans respectively [1].
- Collectively, these results suggest that SMS2 may play a crucial role in the lipid metabolism in acrosome formation and the plasma membrane restructuring from late round spermatids to early elongating spermatids [1].
- Furthermore, SMS2 was shown to associate with the developing acrosome beginning in late round spermatid through elongating spermatids (but not late elongate spermatids) and the cell membrane in studies using fluorescent microscopy and immunohistochemistry [1].
- Cellular localization of sphingomyelin synthase 2 in the seminiferous epithelium of adult rat testes [1].
Associations of SGMS2 with chemical compounds
- Sphingomyelin synthase 2 (SMS2) is an enzyme that catalyzes the conversion of phosphatidylcholine and ceramide to sphingomyelin and diacylglycerol, and it is crucial to cellular lipid metabolism [1].
References
- Cellular localization of sphingomyelin synthase 2 in the seminiferous epithelium of adult rat testes. Lee, N.P., Mruk, D.D., Xia, W., Cheng, C.Y. J. Endocrinol. (2007) [Pubmed]
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