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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Candidiasis


Psychiatry related information on Candidiasis


High impact information on Candidiasis


Chemical compound and disease context of Candidiasis


Biological context of Candidiasis


Anatomical context of Candidiasis


Gene context of Candidiasis

  • Therapeutic ablation of IL-4 or IL-10 greatly increased resistance to candidiasis [28].
  • Taken together, our findings suggest that SET1 regulates multiple processes important to the pathogenesis of candidiasis [29].
  • Despite the importance of interferon (IFN)-gamma, tumor necrosis factor (TNF), and interleukin (IL)-18 for host defense against candidiasis, the pathways leading to their stimulation by Candida albicans are unclear [30].
  • The secreted aspartyl proteinases Sap1 and Sap2 cause tissue damage in an in vitro model of vaginal candidiasis based on reconstituted human vaginal epithelium [31].
  • We implicate C. albicans NOT5 in the pathogenesis of disseminated candidiasis (DC) induced by intravenous infection among neutropenic and nonimmunosuppressed mice, as well as in that of OPC in mice immunosuppressed with corticosteroids [32].

Analytical, diagnostic and therapeutic context of Candidiasis


  1. A randomized trial comparing fluconazole with clotrimazole troches for the prevention of fungal infections in patients with advanced human immunodeficiency virus infection. NIAID AIDS Clinical Trials Group. Powderly, W.G., Finkelstein, D., Feinberg, J., Frame, P., He, W., van der Horst, C., Koletar, S.L., Eyster, M.E., Carey, J., Waskin, H. N. Engl. J. Med. (1995) [Pubmed]
  2. Autoimmune vitiligo: detection of antibodies to melanin-producing cells. Hertz, K.C., Gazze, L.A., Kirkpatrick, C.H., Katz, S.I. N. Engl. J. Med. (1977) [Pubmed]
  3. A randomized, double-blind trial of nystatin therapy for the candidiasis hypersensitivity syndrome. Dismukes, W.E., Wade, J.S., Lee, J.Y., Dockery, B.K., Hain, J.D. N. Engl. J. Med. (1990) [Pubmed]
  4. Ketoconazole-resistant Candida esophagitis in patients with acquired immunodeficiency syndrome. Tavitian, A., Raufman, J.P., Rosenthal, L.E., Weber, J., Webber, C.A., Dincsoy, H.P. Gastroenterology (1986) [Pubmed]
  5. A common and recurrent 13-bp deletion in the autoimmune regulator gene in British kindreds with autoimmune polyendocrinopathy type 1. Pearce, S.H., Cheetham, T., Imrie, H., Vaidya, B., Barnes, N.D., Bilous, R.W., Carr, D., Meeran, K., Shaw, N.J., Smith, C.S., Toft, A.D., Williams, G., Kendall-Taylor, P. Am. J. Hum. Genet. (1998) [Pubmed]
  6. Comparison of immunosuppressive effects of cyclosporine A in a murine model of systemic candidiasis and of localized thrushlike lesions. Krause, M.W., Schaffner, A. Infect. Immun. (1989) [Pubmed]
  7. Candidal costochondritis responsive to ketoconazole in an iv drug abuser. Grubb, B.P., Manders, M.M., Haile, C.A. Postgraduate medicine. (1986) [Pubmed]
  8. Familial hypoparathyroidism with candidiasis and mental retardation. Pisanty, S., Garfunkel, A. Oral Surg. Oral Med. Oral Pathol. (1977) [Pubmed]
  9. Resolution of refractory AIDS-related mucosal candidiasis after initiation of didanosine plus saquinavir. Zingman, B.S. N. Engl. J. Med. (1996) [Pubmed]
  10. Treatment of chronic oral candidiasis with clotrimazole troches. A controlled clinical trial. Kirkpatrick, C.H., Alling, D.W. N. Engl. J. Med. (1978) [Pubmed]
  11. Disseminated candidiasis in a patient with acute leukemia. Successful treatment with miconazole. Katz, M.E., Cassileth, P.A. JAMA (1977) [Pubmed]
  12. Impaired neutrophil response and CD4+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans. Romani, L., Mencacci, A., Cenci, E., Spaccapelo, R., Toniatti, C., Puccetti, P., Bistoni, F., Poli, V. J. Exp. Med. (1996) [Pubmed]
  13. Neutralizing antibody to interleukin 4 induces systemic protection and T helper type 1-associated immunity in murine candidiasis. Romani, L., Mencacci, A., Grohmann, U., Mocci, S., Mosci, P., Puccetti, P., Bistoni, F. J. Exp. Med. (1992) [Pubmed]
  14. High-dose beclomethasone inhaler in the treatment of asthma. Smith, M.J., Hodson, M.E. Lancet (1983) [Pubmed]
  15. Fatal disseminated candidiasis due to amphotericin-B-resistant Candida guilliermondii. Dick, J.D., Rosengard, B.R., Merz, W.G., Stuart, R.K., Hutchins, G.M., Saral, R. Ann. Intern. Med. (1985) [Pubmed]
  16. Disseminated candidiasis after intravenous use of oral methadone. Scheidegger, C., Pietrzak, J., Frei, R. Ann. Intern. Med. (1991) [Pubmed]
  17. Itraconazole versus fluconazole for prevention of fungal infections in patients receiving allogeneic stem cell transplants. Marr, K.A., Crippa, F., Leisenring, W., Hoyle, M., Boeckh, M., Balajee, S.A., Nichols, W.G., Musher, B., Corey, L. Blood (2004) [Pubmed]
  18. Disseminated candidiasis and hepatic malarial infection in mannose-binding-lectin-A-deficient mice. Lee, S.J., Gonzalez-Aseguinolaza, G., Nussenzweig, M.C. Mol. Cell. Biol. (2002) [Pubmed]
  19. Ash1 protein, an asymmetrically localized transcriptional regulator, controls filamentous growth and virulence of Candida albicans. Inglis, D.O., Johnson, A.D. Mol. Cell. Biol. (2002) [Pubmed]
  20. B cell-independent selection of memory T cells after mucosal immunization with Candida albicans. Jones-Carson, J., Vazquez-Torres, F.A., Balish, E. J. Immunol. (1997) [Pubmed]
  21. AIRE mutations and human leukocyte antigen genotypes as determinants of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy phenotype. Halonen, M., Eskelin, P., Myhre, A.G., Perheentupa, J., Husebye, E.S., Kämpe, O., Rorsman, F., Peltonen, L., Ulmanen, I., Partanen, J. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  22. Downregulation of IFN-gamma production in patients with recurrent vaginal candidiasis. Carvalho, L.P., Bacellar, O., Neves, N., de Jesus, A.R., Carvalho, E.M. J. Allergy Clin. Immunol. (2002) [Pubmed]
  23. A randomized, double-blind comparison of itraconazole oral solution and fluconazole tablets in the treatment of esophageal candidiasis. Wilcox, C.M., Darouiche, R.O., Laine, L., Moskovitz, B.L., Mallegol, I., Wu, J. J. Infect. Dis. (1997) [Pubmed]
  24. Elimination of mouse splenic macrophages correlates with increased susceptibility to experimental disseminated candidiasis. Qian, Q., Jutila, M.A., Van Rooijen, N., Cutler, J.E. J. Immunol. (1994) [Pubmed]
  25. CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis. Mencacci, A., Montagnoli, C., Bacci, A., Cenci, E., Pitzurra, L., Spreca, A., Kopf, M., Sharpe, A.H., Romani, L. J. Immunol. (2002) [Pubmed]
  26. Detection of human papillomavirus and Epstein-Barr virus DNA sequences in oral mucosa of HIV-infected patients by the polymerase chain reaction. Snijders, P.J., Schulten, E.A., Mullink, H., ten Kate, R.W., Jiwa, M., van der Waal, I., Meijer, C.J., Walboomers, J.M. Am. J. Pathol. (1990) [Pubmed]
  27. The effect of prophylactic fluconazole on the clinical spectrum of fungal diseases in bone marrow transplant recipients with special attention to hepatic candidiasis. An autopsy study of 355 patients. van Burik, J.H., Leisenring, W., Myerson, D., Hackman, R.C., Shulman, H.M., Sale, G.E., Bowden, R.A., McDonald, G.B. Medicine (Baltimore) (1998) [Pubmed]
  28. Defective antifungal T-helper 1 (TH1) immunity in a murine model of allogeneic T-cell-depleted bone marrow transplantation and its restoration by treatment with TH2 cytokine antagonists. Mencacci, A., Perruccio, K., Bacci, A., Cenci, E., Benedetti, R., Martelli, M.F., Bistoni, F., Coffman, R., Velardi, A., Romani, L. Blood (2001) [Pubmed]
  29. Candida albicans SET1 encodes a histone 3 lysine 4 methyltransferase that contributes to the pathogenesis of invasive candidiasis. Raman, S.B., Nguyen, M.H., Zhang, Z., Cheng, S., Jia, H.Y., Weisner, N., Iczkowski, K., Clancy, C.J. Mol. Microbiol. (2006) [Pubmed]
  30. The role of endogenous interleukin (IL)-18, IL-12, IL-1beta, and tumor necrosis factor-alpha in the production of interferon-gamma induced by Candida albicans in human whole-blood cultures. Netea, M.G., Stuyt, R.J., Kim, S.H., Van der Meer, J.W., Kullberg, B.J., Dinarello, C.A. J. Infect. Dis. (2002) [Pubmed]
  31. The secreted aspartyl proteinases Sap1 and Sap2 cause tissue damage in an in vitro model of vaginal candidiasis based on reconstituted human vaginal epithelium. Schaller, M., Bein, M., Korting, H.C., Baur, S., Hamm, G., Monod, M., Beinhauer, S., Hube, B. Infect. Immun. (2003) [Pubmed]
  32. The role of Candida albicans NOT5 in virulence depends upon diverse host factors in vivo. Cheng, S., Clancy, C.J., Checkley, M.A., Zhang, Z., Wozniak, K.L., Seshan, K.R., Jia, H.Y., Fidel, P., Cole, G., Nguyen, M.H. Infect. Immun. (2005) [Pubmed]
  33. Detection of circulating candida enolase by immunoassay in patients with cancer and invasive candidiasis. Walsh, T.J., Hathorn, J.W., Sobel, J.D., Merz, W.G., Sanchez, V., Maret, S.M., Buckley, H.R., Pfaller, M.A., Schaufele, R., Sliva, C. N. Engl. J. Med. (1991) [Pubmed]
  34. Fluconazole versus itraconazole for candida esophagitis in acquired immunodeficiency syndrome. Candida Esophagitis. Barbaro, G., Barbarini, G., Calderon, W., Grisorio, B., Alcini, P., Di Lorenzo, G. Gastroenterology (1996) [Pubmed]
  35. Neutrophil Fc gamma RI as target for immunotherapy of invasive candidiasis. van Spriel, A.B., van den Herik-Oudijk, I.E., van de Winkel, J.G. J. Immunol. (2001) [Pubmed]
  36. Ketoconazole in the prevention of candidiasis in patients with cancer. A prospective, randomized, controlled, double-blind study. Hansen, R.M., Reinerio, N., Sohnle, P.G., Abrams, R.A., Ritch, P.S., Libnoch, J.A., Anderson, T. Arch. Intern. Med. (1987) [Pubmed]
  37. Oral transmission of Candida albicans between partners in HIV-infected couples could contribute to dissemination of fluconazole-resistant isolates. Dromer, F., Improvisi, L., Dupont, B., Eliaszewicz, M., Pialoux, G., Fournier, S., Feuillie, V. AIDS (1997) [Pubmed]
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