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Gene Review

GSX2  -  GS homeobox 2

Homo sapiens

Synonyms: GSH2, Gsh2, Homeobox protein GSH-2
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High impact information on GSH2

  • During the embryonic period, many olfactory bulb (OB) interneurons arise in the lateral ganglionic eminence (LGE) from precursor cells expressing Dlx2, Gsh2 and Er81 transcription factors [1].
  • The 56-Da protein corresponds to the complete GSH2 open reading frame, while the subfragments are produced following the cleavage of this larger protein by a metalloprotease [2].
  • Mitochondrial DNA depletion significantly lowered glutathione reductase activity, glutathione (GSH) content, and consistently altered the GSH2 : oxidized glutathione ratio in all of the rho0 cell lines, albeit to differing extents, indicating the most oxidized redox state in bone rho0 cells [3].
  • Gsh2 homeobox transcription factors play a crucial role in the development of GABAergic neurons [4].
  • Heterozygous truncating mutation in the human homeobox gene GSH2 has no discernable phenotypic effect [5].


  1. Generation of GABAergic and dopaminergic interneurons from endogenous embryonic olfactory bulb precursor cells. Verga??o-Vera, E., Yusta-Boyo, M.J., de Castro, F., Bernad, A., de Pablo, F., Vicario-Abej??n, C. Development (2006) [Pubmed]
  2. The glutathione synthetase of Schizosaccharomyces pombe is synthesized as a homodimer but retains full activity when present as a heterotetramer. Phlippen, N., Hoffmann, K., Fischer, R., Wolf, K., Zimmermann, M. J. Biol. Chem. (2003) [Pubmed]
  3. Antioxidant defences and homeostasis of reactive oxygen species in different human mitochondrial DNA-depleted cell lines. Vergani, L., Floreani, M., Russell, A., Ceccon, M., Napoli, E., Cabrelle, A., Valente, L., Bragantini, F., Leger, B., Dabbeni-Sala, F. Eur. J. Biochem. (2004) [Pubmed]
  4. A mammalian dpy-19 homologue is expressed in GABAergic neurons. Kurokawa, K., Tamura, Y., Kataoka, Y., Yamada, H., Nakamura, T., Taki, K., Kudo, M. Medical molecular morphology. (2005) [Pubmed]
  5. Heterozygous truncating mutation in the human homeobox gene GSH2 has no discernable phenotypic effect. Dauwerse, J.G., De Die-Smulders, C.E., Bakker, E., Breuning, M.H., Peters, D.J. J. Med. Genet. (2002) [Pubmed]
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