The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Rap1b  -  RAP1B, member of RAS oncogene family

Rattus norvegicus

Synonyms: GTP-binding protein smg p21B, Ras-related protein Rap-1b
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Rap1b

  • These findings indicate that hyperglycemia and HG cause an activation and up-regulation of Rap1b in renal glomeruli and in cultured MCs, which then stimulates FN synthesis [1].

High impact information on Rap1b

  • Here we report that cAMP-dependent hormonal stimulation of DNA synthesis requires Rap1b in a manner dependent on its phosphorylation by protein kinase A [2].
  • The oncogenic property of Rap1b was revealed in a model system in which cAMP stimulates cell proliferation and was linked to Rap's ability to promote S phase entry [2].
  • We have now tested the significance of the mitogenic action of Rap1b in a physiologically relevant model, the differentiated thyroid follicular cells, a system that requires thyroid-stimulating hormone (TSH), acting via cAMP, to mediate a full mitogenic response [2].
  • Similarly, in vitro exposure of MCs to HG led to an up-regulation of Rap1b with concomitant increase in fibronectin (FN) mRNA and protein expression [1].
  • Transfection of Rap1b mutants S17N (Ser --> Asn) or T61R (Thr --> Arg) in MCs inhibited the HG-induced increased FN synthesis [1].

Biological context of Rap1b


Associations of Rap1b with chemical compounds


Other interactions of Rap1b

  • B-Raf, and not Raf-1, expression was increased in MCs transfected with Rap1b [1].


  1. High glucose stimulates synthesis of fibronectin via a novel protein kinase C, Rap1b, and B-Raf signaling pathway. Lin, S., Sahai, A., Chugh, S.S., Pan, X., Wallner, E.I., Danesh, F.R., Lomasney, J.W., Kanwar, Y.S. J. Biol. Chem. (2002) [Pubmed]
  2. On the mitogenic properties of Rap1b: cAMP-induced G(1)/S entry requires activated and phosphorylated Rap1b. Ribeiro-Neto, F., Urbani, J., Lemee, N., Lou, L., Altschuler, D.L. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
WikiGenes - Universities