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Gene Review

Rap1b  -  RAS related protein 1b

Mus musculus

Synonyms: 2810443E11Rik, GTP-binding protein smg p21B, Ras-related protein Rap-1b
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Disease relevance of Rap1b


High impact information on Rap1b

  • Rap1b, an abundant small GTPase in platelets, becomes rapidly activated upon stimulation with agonists [1].
  • Rap1b is required for normal platelet function and hemostasis in mice [1].
  • On the other hand, retroviral expression of CalDAG-GEFI, a Rap1 exchange factor identified by megakaryocyte gene profiling as a candidate integrin regulator, enhanced agonist-induced activation of Rap1b and fibrinogen binding to alphaIIbbeta3 (P < 0.01) [2].
  • cAMP-dependent oncogenic action of Rap1b in the thyroid gland [3].
  • cAMP signaling leads to activation and phosphorylation of Rap1b [3].

Biological context of Rap1b


Anatomical context of Rap1b

  • These studies establish that Rap1b can augment agonist-induced ligand binding to alpha(IIb)beta(3) through effects on integrin affinity, possibly by modulating alpha(IIb)beta(3) interactions with the actin cytoskeleton [5].

Associations of Rap1b with chemical compounds

  • These data provide genetic evidence that Rap1b is involved in a common pathway of integrin activation, is required for normal hemostasis in vivo, and may be a clinically relevant antithrombotic therapy target [1].
  • Cyclic AMP-dependent activation of Rap1b [6].
  • The Rap1b effect was cell-autonomous and was prevented by pre-treating cells with cytochalasin D or latrunculin A to inhibit actin polymerization [5].

Analytical, diagnostic and therapeutic context of Rap1b


  1. Rap1b is required for normal platelet function and hemostasis in mice. Chrzanowska-Wodnicka, M., Smyth, S.S., Schoenwaelder, S.M., Fischer, T.H., White, G.C. J. Clin. Invest. (2005) [Pubmed]
  2. Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling. Eto, K., Murphy, R., Kerrigan, S.W., Bertoni, A., Stuhlmann, H., Nakano, T., Leavitt, A.D., Shattil, S.J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. cAMP-dependent oncogenic action of Rap1b in the thyroid gland. Ribeiro-Neto, F., Leon, A., Urbani-Brocard, J., Lou, L., Nyska, A., Altschuler, D.L. J. Biol. Chem. (2004) [Pubmed]
  4. Identification of up-regulated Ras-like GTPase, Rap1b, by suppression subtractive hybridization. Lin, S., Chugh, S., Pan, X., Wallner, E.I., Wada, J., Kanwar, Y.S. Kidney Int. (2001) [Pubmed]
  5. Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton. Bertoni, A., Tadokoro, S., Eto, K., Pampori, N., Parise, L.V., White, G.C., Shattil, S.J. J. Biol. Chem. (2002) [Pubmed]
  6. Cyclic AMP-dependent activation of Rap1b. Altschuler, D.L., Peterson, S.N., Ostrowski, M.C., Lapetina, E.G. J. Biol. Chem. (1995) [Pubmed]
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