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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Kif2c  -  kinesin family member 2C

Rattus norvegicus

Synonyms: Kinesin-like protein KIF2C, Kinesin-related protein 2, Krp2, MCAK, Mitotic centromere-associated kinesin
 
 
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High impact information on Kif2c

  • Here we analyzed human cells depleted of the ubiquitous Ca(2+)/calmodulin-dependent protein kinase IIgamma isoform (CaMKIIgamma) by RNA interference and found that CaMKIIgamma was necessary to suppress MCAK depolymerase activity in vivo [1].
  • MCAK, a member of the kinesin-13 family, is a microtubule (MT) depolymerase that is necessary to ensure proper kinetochore MT attachment during spindle formation [1].
  • Aurora B inhibited MCAK's microtubule depolymerizing activity in vitro, and phospho-mimic (S/E) mutants of MCAK inhibited depolymerization in vivo [2].
  • Expression of either MCAK (S/E) or MCAK (S/A) mutants increased the frequency of syntelic microtubule-kinetochore attachments and mono-oriented chromosomes [2].
  • Aurora B regulates MCAK at the mitotic centromere [2].

References

  1. CaMKIIgamma-mediated inactivation of the Kin I kinesin MCAK is essential for bipolar spindle formation. Holmfeldt, P., Zhang, X., Stenmark, S., Walczak, C.E., Gullberg, M. EMBO J. (2005) [Pubmed]
  2. Aurora B regulates MCAK at the mitotic centromere. Andrews, P.D., Ovechkina, Y., Morrice, N., Wagenbach, M., Duncan, K., Wordeman, L., Swedlow, J.R. Dev. Cell (2004) [Pubmed]
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