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Gene Review

AURKB  -  aurora kinase B

Homo sapiens

Synonyms: AIK2, AIM-1, AIM1, AIRK2, ARK-2, ...
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Disease relevance of AURKB


High impact information on AURKB

  • Phosphorylation by Aurora B, which corrects improper kinetochore-microtubule connections in vivo, reduces the affinity of the Ndc80 complex for microtubules in vitro [4].
  • The N terminus of Hec1 is phosphorylated by Aurora B kinase in vitro, and cells expressing N-terminal nonphosphorylatable mutants of Hec1 exhibit an increase in merotelic attachments, hyperstretching of centromeres, and errors in chromosome segregation [5].
  • NoCut depends on the Aurora kinase Ipl1 and the anillin-related proteins Boi1 and Boi2, which localize to the site of cleavage in an Ipl1-dependent manner and act as abscission inhibitors [6].
  • Here we report the identification of Dasra A and Dasra B, two new components of the vertebrate chromosomal passenger complex containing Incenp, Survivin, and the kinase Aurora B, and demonstrate that this complex is required for chromatin-induced microtubule stabilization and spindle formation [7].
  • A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity [8].

Chemical compound and disease context of AURKB


Biological context of AURKB


Anatomical context of AURKB


Associations of AURKB with chemical compounds


Physical interactions of AURKB

  • Human aurora-B binds to a proteasome alpha-subunit HC8 and undergoes degradation in a proteasome-dependent manner [19].
  • These data suggest that Aurora B kinase activity and the formation of the Aurora B/INCENP/survivin complex both contribute to its proper localization [22].

Enzymatic interactions of AURKB


Regulatory relationships of AURKB


Other interactions of AURKB


Analytical, diagnostic and therapeutic context of AURKB


  1. Overexpression of aurora B kinase (AURKB) in primary non-small cell lung carcinoma is frequent, generally driven from one allele, and correlates with the level of genetic instability. Smith, S.L., Bowers, N.L., Betticher, D.C., Gautschi, O., Ratschiller, D., Hoban, P.R., Booton, R., Santibáñez-Koref, M.F., Heighway, J. Br. J. Cancer (2005) [Pubmed]
  2. Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells. Tatsuka, M., Katayama, H., Ota, T., Tanaka, T., Odashima, S., Suzuki, F., Terada, Y. Cancer Res. (1998) [Pubmed]
  3. Targeting Aurora kinases for the treatment of prostate cancer. Lee, E.C., Frolov, A., Li, R., Ayala, G., Greenberg, N.M. Cancer Res. (2006) [Pubmed]
  4. The Conserved KMN Network Constitutes the Core Microtubule-Binding Site of the Kinetochore. Cheeseman, I.M., Chappie, J.S., Wilson-Kubalek, E.M., Desai, A. Cell (2006) [Pubmed]
  5. Kinetochore microtubule dynamics and attachment stability are regulated by hec1. Deluca, J.G., Gall, W.E., Ciferri, C., Cimini, D., Musacchio, A., Salmon, E.D. Cell (2006) [Pubmed]
  6. The NoCut pathway links completion of cytokinesis to spindle midzone function to prevent chromosome breakage. Norden, C., Mendoza, M., Dobbelaere, J., Kotwaliwale, C.V., Biggins, S., Barral, Y. Cell (2006) [Pubmed]
  7. The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Sampath, S.C., Ohi, R., Leismann, O., Salic, A., Pozniakovski, A., Funabiki, H. Cell (2004) [Pubmed]
  8. A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. Li, Y., Kao, G.D., Garcia, B.A., Shabanowitz, J., Hunt, D.F., Qin, J., Phelan, C., Lazar, M.A. Genes Dev. (2006) [Pubmed]
  9. Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation. Sorrentino, R., Libertini, S., Pallante, P.L., Troncone, G., Palombini, L., Bavetsias, V., Spalletti-Cernia, D., Laccetti, P., Linardopoulos, S., Chieffi, P., Fusco, A., Portella, G. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  10. Rebamipide inhibits gastric cancer growth by targeting survivin and Aurora-B. Tarnawski, A., Pai, R., Chiou, S.K., Chai, J., Chu, E.C. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  11. Histone deacetylase inhibitors and paclitaxel cause synergistic effects on apoptosis and microtubule stabilization in papillary serous endometrial cancer cells. Dowdy, S.C., Jiang, S., Zhou, X.C., Hou, X., Jin, F., Podratz, K.C., Jiang, S.W. Mol. Cancer Ther. (2006) [Pubmed]
  12. CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis. Zeitlin, S.G., Shelby, R.D., Sullivan, K.F. J. Cell Biol. (2001) [Pubmed]
  13. Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo. Wheatley, S.P., Henzing, A.J., Dodson, H., Khaled, W., Earnshaw, W.C. J. Biol. Chem. (2004) [Pubmed]
  14. cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2. Shindo, M., Nakano, H., Kuroyanagi, H., Shirasawa, T., Mihara, M., Gilbert, D.J., Jenkins, N.A., Copeland, N.G., Yagita, H., Okumura, K. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  15. Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. Sasai, K., Katayama, H., Stenoien, D.L., Fujii, S., Honda, R., Kimura, M., Okano, Y., Tatsuka, M., Suzuki, F., Nigg, E.A., Earnshaw, W.C., Brinkley, W.R., Sen, S. Cell Motil. Cytoskeleton (2004) [Pubmed]
  16. Neither Aurora B Activity nor Histone H3 Phosphorylation Is Essential for Chromosome Condensation During Meiotic Maturation of Porcine Oocytes. Jelínková, L., Kubelka, M. Biol. Reprod. (2006) [Pubmed]
  17. Downregulation of an AIM-1 kinase couples with megakaryocytic polyploidization of human hematopoietic cells. Kawasaki, A., Matsumura, I., Miyagawa Ji, n.u.l.l., Ezoe, S., Tanaka, H., Terada, Y., Tatsuka, M., Machii, T., Miyazaki, H., Furukawa, Y., Kanakura, Y. J. Cell Biol. (2001) [Pubmed]
  18. Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells. Meraldi, P., Honda, R., Nigg, E.A. EMBO J. (2002) [Pubmed]
  19. Human aurora-B binds to a proteasome alpha-subunit HC8 and undergoes degradation in a proteasome-dependent manner. Shu, F., Guo, S., Dang, Y., Qi, M., Zhou, G., Guo, Z., Zhang, Y., Wu, C., Zhao, S., Yu, L. Mol. Cell. Biochem. (2003) [Pubmed]
  20. Frequent alterations in the expression of serine/threonine kinases in human cancers. Capra, M., Nuciforo, P.G., Confalonieri, S., Quarto, M., Bianchi, M., Nebuloni, M., Boldorini, R., Pallotti, F., Viale, G., Gishizky, M.L., Draetta, G.F., Di Fiore, P.P. Cancer Res. (2006) [Pubmed]
  21. Estrogen mediates phosphorylation of histone H3 in ovarian follicle and mammary epithelial tumor cells via the mitotic kinase, Aurora B. Ruiz-Cortés, Z.T., Kimmins, S., Monaco, L., Burns, K.H., Sassone-Corsi, P., Murphy, B.D. Mol. Endocrinol. (2005) [Pubmed]
  22. Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. Honda, R., Körner, R., Nigg, E.A. Mol. Biol. Cell (2003) [Pubmed]
  23. Functional significance of the specific sites phosphorylated in desmin at cleavage furrow: Aurora-B may phosphorylate and regulate type III intermediate filaments during cytokinesis coordinatedly with Rho-kinase. Kawajiri, A., Yasui, Y., Goto, H., Tatsuka, M., Takahashi, M., Nagata, K., Inagaki, M. Mol. Biol. Cell (2003) [Pubmed]
  24. Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis. Minoshima, Y., Kawashima, T., Hirose, K., Tonozuka, Y., Kawajiri, A., Bao, Y.C., Deng, X., Tatsuka, M., Narumiya, S., May, W.S., Nosaka, T., Semba, K., Inoue, T., Satoh, T., Inagaki, M., Kitamura, T. Dev. Cell (2003) [Pubmed]
  25. Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis. Yasui, Y., Urano, T., Kawajiri, A., Nagata, K., Tatsuka, M., Saya, H., Furukawa, K., Takahashi, T., Izawa, I., Inagaki, M. J. Biol. Chem. (2004) [Pubmed]
  26. Phosphorylation of ZEN-4/MKLP1 by aurora B regulates completion of cytokinesis. Guse, A., Mishima, M., Glotzer, M. Curr. Biol. (2005) [Pubmed]
  27. Mitotic requirement for aurora A kinase is bypassed in the absence of aurora B kinase. Yang, H., Burke, T., Dempsey, J., Diaz, B., Collins, E., Toth, J., Beckmann, R., Ye, X. FEBS Lett. (2005) [Pubmed]
  28. Destruction box-dependent degradation of aurora B is mediated by the anaphase-promoting complex/cyclosome and Cdh1. Stewart, S., Fang, G. Cancer Res. (2005) [Pubmed]
  29. Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20. Morrow, C.J., Tighe, A., Johnson, V.L., Scott, M.I., Ditchfield, C., Taylor, S.S. J. Cell. Sci. (2005) [Pubmed]
  30. Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer. Chang, J.L., Chen, T.H., Wang, C.F., Chiang, Y.H., Huang, Y.L., Wong, F.H., Chou, C.K., Chen, C.M. Exp. Cell Res. (2006) [Pubmed]
  31. Inhibition of survivin and aurora B kinase sensitizes mesothelioma cells by enhancing mitotic arrests. Kim, K.W., Mutter, R.W., Willey, C.D., Subhawong, T.K., Shinohara, E.T., Albert, J.M., Ling, G., Cao, C., Gi, Y.J., Lu, B. Int. J. Radiat. Oncol. Biol. Phys. (2007) [Pubmed]
  32. Anillin localization defect in cardiomyocyte binucleation. Engel, F.B., Schebesta, M., Keating, M.T. J. Mol. Cell. Cardiol. (2006) [Pubmed]
  33. Expression of Aurora-B kinase and phosphorylated histone H3 in hepatocellular carcinoma. Sistayanarain, A., Tsuneyama, K., Zheng, H., Takahashi, H., Nomoto, K., Cheng, C., Murai, Y., Tanaka, A., Takano, Y. Anticancer Res. (2006) [Pubmed]
  34. Identification and characterization of STK12/Aik2: a human gene related to aurora of Drosophila and yeast IPL1. Kimura, M., Matsuda, Y., Yoshioka, T., Sumi, N., Okano, Y. Cytogenet. Cell Genet. (1998) [Pubmed]
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