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Gene Review

Kif2c  -  kinesin family member 2C

Mus musculus

Synonyms: 4930402F02Rik, ESTM5, Kinesin-like protein KIF2C, Knsl6, MCAK, ...
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High impact information on Kif2c

  • We discuss the possible functions of MCAK at the inner centromere domain and at the perikinetochoric ring during both meiotic divisions [1].
  • During chromosome congression to the metaphase II plate, MCAK relocalises and appears as a ring below each sister kinetochore [1].
  • We have analysed by immunofluorescence in squashed mouse spermatocytes, the distribution and possible function of MCAK, together with Aurora-B, during both meiotic divisions [1].

Biological context of Kif2c

  • Thus, MCAK shows a "cone"-like three-dimensional distribution beneath and surrounding the closely associated sister kinetochores [1].
  • We propose that the perikinetochoric rings of MCAK and Aurora-B define a novel transient centromere domain at least in mouse chromosomes during meiosis [1].

Anatomical context of Kif2c


  1. A Perikinetochoric Ring Defined by MCAK and Aurora-B as a Novel Centromere Domain. Parra, M.T., G??mez, R., Viera, A., Page, J., Calvente, A., Wordeman, L., Rufas, J.S., Suja, J.A. PLoS Genet. (2006) [Pubmed]
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