Gene Review:
Kif2c - kinesin family member 2C
Mus musculus
Synonyms:
4930402F02Rik, ESTM5, Kinesin-like protein KIF2C, Knsl6, MCAK, ...
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High impact information on Kif2c
- We discuss the possible functions of MCAK at the inner centromere domain and at the perikinetochoric ring during both meiotic divisions [1].
- During chromosome congression to the metaphase II plate, MCAK relocalises and appears as a ring below each sister kinetochore [1].
- We have analysed by immunofluorescence in squashed mouse spermatocytes, the distribution and possible function of MCAK, together with Aurora-B, during both meiotic divisions [1].
Biological context of Kif2c
- Thus, MCAK shows a "cone"-like three-dimensional distribution beneath and surrounding the closely associated sister kinetochores [1].
- We propose that the perikinetochoric rings of MCAK and Aurora-B define a novel transient centromere domain at least in mouse chromosomes during meiosis [1].
Anatomical context of Kif2c
- Our results demonstrate that the redistribution of MCAK at prometaphase II/metaphase II centromeres depends on tension across the centromere and/or on the interaction of microtubules with kinetochores [1].
References
- A Perikinetochoric Ring Defined by MCAK and Aurora-B as a Novel Centromere Domain. Parra, M.T., G??mez, R., Viera, A., Page, J., Calvente, A., Wordeman, L., Rufas, J.S., Suja, J.A. PLoS Genet. (2006) [Pubmed]
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