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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

let-502  -  Protein LET-502

Caenorhabditis elegans

 
 
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Disease relevance of let-502

 

High impact information on let-502

  • Mutations in let-502 ROCK, a homologue of a RhoA effector in mammals, also cause defects in P cell migration, suggesting that it may be one of several effectors acting downstream of rho-1 during P cell migration [2].
  • However, a nmy-1 null allele displays elongation defects less severe than mutations in let-502 or in the single nonmuscle myosin light chain gene mlc-4 [3].
  • Previously, we described the role of C. elegans genes encoding Rho-binding kinase (let-502) and myosin phosphatase targeting subunit (mel-11) in epidermal cell-shape changes that drive morphogenesis and in spermathecal contraction [4].
 

Other interactions of let-502

  • The morphogenetic function of let-502 and mel-11 is apparently redundant with another pathway since elimination of these two genes resulted in progeny that underwent near-normal elongation [5].

References

  1. Caenorhabditis elegans LET-502 is related to Rho-binding kinases and human myotonic dystrophy kinase and interacts genetically with a homolog of the regulatory subunit of smooth muscle myosin phosphatase to affect cell shape. Wissmann, A., Ingles, J., McGhee, J.D., Mains, P.E. Genes Dev. (1997) [Pubmed]
  2. A RHO GTPase-mediated pathway is required during P cell migration in Caenorhabditis elegans. Spencer, A.G., Orita, S., Malone, C.J., Han, M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  3. The Caenorhabditis elegans nonmuscle myosin genes nmy-1 and nmy-2 function as redundant components of the let-502/Rho-binding kinase and mel-11/myosin phosphatase pathway during embryonic morphogenesis. Piekny, A.J., Johnson, J.L., Cham, G.D., Mains, P.E. Development (2003) [Pubmed]
  4. Rho-binding kinase (LET-502) and myosin phosphatase (MEL-11) regulate cytokinesis in the early Caenorhabditis elegans embryo. Piekny, A.J., Mains, P.E. J. Cell. Sci. (2002) [Pubmed]
  5. Embryonic morphogenesis in Caenorhabditis elegans integrates the activity of LET-502 Rho-binding kinase, MEL-11 myosin phosphatase, DAF-2 insulin receptor and FEM-2 PP2c phosphatase. Piekny, A.J., Wissmann, A., Mains, P.E. Genetics (2000) [Pubmed]
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