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Gene Review

Rok  -  Rho kinase

Drosophila melanogaster

Synonyms: CG9774, DROK, DRhk, DRok, Dmel\CG9774, ...
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High impact information on rok

  • The primary output of Drok signaling is regulating the phosphorylation of nonmuscle myosin regulatory light chain, and hence the activity of myosin II [1].
  • Disruption of the actin cytoskeleton with Latrunculin A, which abolishes cortical rigidity, suppressed the spindle defect. rok RNAi also affected furrowing, which was delayed and slowed, sometimes distorted, and in severe cases blocked altogether [2].
  • Co-expression of dominant negative Rho-kinase and constitutive active Rho1 also induces filopodia formation, with Diaphanous enriched at the tips [3].
  • In the reciprocal pathway, co-expression of dominant negative Rho-kinase and constitutive active Rho1 induces a Rac1-like phenotype [3].
  • These findings indicated that while the assembly of stress fibers in fibroblasts critically involves both ROK and mDia1, in myofibroblasts, the assembly of alpha-SMA-containing stress fibers also occurs independently of ROK and involves Rho/mDia1 [4].

Anatomical context of rok


Other interactions of rok

  • The ROK inhibition-resistant stress fibers and FAs were lost upon the overexpression of the dominant-negative form of mDia1 (a mammalian homolog of Drosophila diaphanous protein) [4].


  1. Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton. Winter, C.G., Wang, B., Ballew, A., Royou, A., Karess, R., Axelrod, J.D., Luo, L. Cell (2001) [Pubmed]
  2. Rho-kinase controls cell shape changes during cytokinesis. Hickson, G.R., Echard, A., O'Farrell, P.H. Curr. Biol. (2006) [Pubmed]
  3. Reciprocal regulation of Rac1 and Rho1 in Drosophila circulating immune surveillance cells. Williams, M.J., Habayeb, M.S., Hultmark, D. J. Cell. Sci. (2007) [Pubmed]
  4. Rho-mediated assembly of stress fibers is differentially regulated in corneal fibroblasts and myofibroblasts. Anderson, S., DiCesare, L., Tan, I., Leung, T., SundarRaj, N. Exp. Cell Res. (2004) [Pubmed]
  5. Identification and characterization of Drosophila homolog of Rho-kinase. Mizuno, T., Amano, M., Kaibuchi, K., Nishida, Y. Gene (1999) [Pubmed]
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