The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ROCK2  -  Rho-associated, coiled-coil containing...

Homo sapiens

Synonyms: KIAA0619, ROCK-II, Rho kinase 2, Rho-associated protein kinase 2, Rho-associated, coiled-coil-containing protein kinase 2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ROCK2

  • The results suggest that common variation in ROCK2 exerts systemic resistance-mediated changes in BP, documenting a novel mechanism for human circulatory control, and suggesting new possibilities for diagnostic profiling and treatment of subjects at risk of developing hypertension [1].

High impact information on ROCK2

  • We demonstrate that macrophage adherence promotes rapid changes in physiological functions that depend on translational upregulation of preformed ROCK-1 mRNA, but not ROCK-2 mRNA [2].
  • Upon binding to RhoA, ROCK-2 becomes autophosphorylated and demonstrates stimulated kinase activity [3].
  • Our analysis indicates that the ribozymes toward ROCK1 can block invasive activity but not the proliferation of HT1080 cells without having any effect on expression of ROCK2 [4].
  • These observations suggest that nucleus-localized ROCK2 targets p300 for phosphorylation to regulate its acetyltransferase activity [5].
  • Because ROCK inhibitors are nonselective with respect to ROCK1 and ROCK2 and also, in some cases, may be nonspecific with respect to other ROCK-related kinases such as myristolated alanine-rich C kinase substrate (MARCKS), protein kinase A, and protein kinase C, the precise role of ROCKs in cardiovascular disease remains unknown [6].

Biological context of ROCK2

  • Common genetic variation (Thr431Asn) at ROCK2 predicts increased BP, systemic vascular resistance (although not large artery compliance), and resistance in response to the endogenous renin-angiotensin system, indicating a resistance vessel-based effect on elevated BP [1].
  • The Asn/Asn genotype (compared with Asn/Thr or Thr/Thr) was associated with greater resting systolic (P<0.001), diastolic (P<0.0001), and mean BP (P<0.0001); allelic variation at ROCK2 accounted for up to approximately 5% of BP variation (P<0.0001) [1].

Anatomical context of ROCK2

  • That this is of importance is supported by the findings that an increased Rho-kinase/ROCK activity in SW13 cells, obtained by overexpressing wild-type ROCK1 and ROCK2, induces stress-fibre formation [7].
  • Taken together, our results demonstrate that the expression and activity of ROCK1 and ROCK2 can be uncoupled in a signal-dependent manner, and further implicate a new function for ROCK2 in the steroid control of tight junction dynamics [8].
  • In this study, first of all we investigated the expression of Rho-kinase (ROCK-2) and then the role of this protein in the control of smooth muscle contraction in the isolated human gallbladder [9].

Other interactions of ROCK2


Analytical, diagnostic and therapeutic context of ROCK2

  • However, with the recent development of ROCK1- and ROCK2-knockout mice, further dissection of ROCK signaling pathways is now possible [6].
  • Nuclear ROCK2 is present in a large protein complex and partially cofractionates with p300 by gel filtration analysis [5].
  • By immunofluorescence, ROCK2 partially colocalizes with p300 in distinct insoluble nuclear structures [5].


  1. Rho kinase polymorphism influences blood pressure and systemic vascular resistance in human twins: role of heredity. Seasholtz, T.M., Wessel, J., Rao, F., Rana, B.K., Khandrika, S., Kennedy, B.P., Lillie, E.O., Ziegler, M.G., Smith, D.W., Schork, N.J., Brown, J.H., O'Connor, D.T. Hypertension (2006) [Pubmed]
  2. PSGL-1 and mTOR regulate translation of ROCK-1 and physiological functions of macrophages. Fox, R., Nhan, T.Q., Law, G.L., Morris, D.R., Liles, W.C., Schwartz, S.M. EMBO J. (2007) [Pubmed]
  3. Role of transglutaminase II in retinoic acid-induced activation of RhoA-associated kinase-2. Singh, U.S., Kunar, M.T., Kao, Y.L., Baker, K.M. EMBO J. (2001) [Pubmed]
  4. Identification of genes responsible for cell migration by a library of randomized ribozymes. Suyama, E., Kawasaki, H., Kasaoka, T., Taira, K. Cancer Res. (2003) [Pubmed]
  5. Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase. Tanaka, T., Nishimura, D., Wu, R.C., Amano, M., Iso, T., Kedes, L., Nishida, H., Kaibuchi, K., Hamamori, Y. J. Biol. Chem. (2006) [Pubmed]
  6. Physiological role of ROCKs in the cardiovascular system. Noma, K., Oyama, N., Liao, J.K. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  7. Expression of BRG1, a human SWI/SNF component, affects the organisation of actin filaments through the RhoA signalling pathway. Asp, P., Wihlborg, M., Karlén, M., Farrants, A.K. J. Cell. Sci. (2002) [Pubmed]
  8. Selective glucocorticoid control of Rho kinase isoforms regulate cell-cell interactions. Rubenstein, N.M., Callahan, J.A., Lo, D.H., Firestone, G.L. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  9. Contribution of Rho-kinase in human gallbladder contractions. Büyükafşar, K., Akça, T., Nalan Tiftik, R., Sahan-Firat, S., Aydin, S. Eur. J. Pharmacol. (2006) [Pubmed]
  10. Hypoxia-induced upregulation of endothelial small G protein RhoA and Rho-kinase/ROCK2 inhibits eNOS expression. Jin, H.G., Yamashita, H., Nagano, Y., Fukuba, H., Hiji, M., Ohtsuki, T., Takahashi, T., Kohriyama, T., Kaibuchi, K., Matsumoto, M. Neurosci. Lett. (2006) [Pubmed]
WikiGenes - Universities