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Gene Review

ROCK2  -  Rho-associated, coiled-coil containing...

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Disease relevance of ROCK2

  • Our findings indicate that p160ROCK-mediated Ca2+ sensitization is involved in the pathophysiology of hypertension and suggest that compounds that inhibit this process might be useful therapeutically [1].

High impact information on ROCK2

  • We identified the Y-27632 target as a Rho-associated protein kinase, p160ROCK [1].
  • Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension [1].
  • Shear stress-induced cell alignment and stress fiber formation were inhibited by the dominant-negative mutants of Rho and p160ROCK, but not by the dominant-negative mutant of Cdc42, indicating that the Rho-p160ROCK pathway regulates the cytoskeletal reorganization in response to shear stress [2].
  • The Rho-associated protein kinase p160ROCK is required for centrosome positioning [3].
  • These observations suggest that nucleus-localized ROCK2 targets p300 for phosphorylation to regulate its acetyltransferase activity [4].

Chemical compound and disease context of ROCK2


Biological context of ROCK2


Anatomical context of ROCK2

  • While the inhibition of p160ROCK and its ensuing disruption of actin filaments decreased the basal c-fos activity in static ECs (no flow), it did not affect the shear-inductive effect [6].

Analytical, diagnostic and therapeutic context of ROCK2

  • Nuclear ROCK2 is present in a large protein complex and partially cofractionates with p300 by gel filtration analysis [4].
  • By immunofluorescence, ROCK2 partially colocalizes with p300 in distinct insoluble nuclear structures [4].
  • The inhibition of a Rho-associated kinase, p160ROCK, decreased the traction force and migration speed under both static and shear conditions and eliminated the shear-enhancement of migration speed [7].
  • Precipitating antibody concentration responses to crude northern fowl mite extract (CME) and bovine serum albumin (BSA) injections were compared in White Rock and Fayoumi hens with two-dimensional immunoelectrophoresis and rocket electrophoresis [8].


  1. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Uehata, M., Ishizaki, T., Satoh, H., Ono, T., Kawahara, T., Morishita, T., Tamakawa, H., Yamagami, K., Inui, J., Maekawa, M., Narumiya, S. Nature (1997) [Pubmed]
  2. Distinct roles for the small GTPases Cdc42 and Rho in endothelial responses to shear stress. Li, S., Chen, B.P., Azuma, N., Hu, Y.L., Wu, S.Z., Sumpio, B.E., Shyy, J.Y., Chien, S. J. Clin. Invest. (1999) [Pubmed]
  3. The Rho-associated protein kinase p160ROCK is required for centrosome positioning. Chevrier, V., Piel, M., Collomb, N., Saoudi, Y., Frank, R., Paintrand, M., Narumiya, S., Bornens, M., Job, D. J. Cell Biol. (2002) [Pubmed]
  4. Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase. Tanaka, T., Nishimura, D., Wu, R.C., Amano, M., Iso, T., Kedes, L., Nishida, H., Kaibuchi, K., Hamamori, Y. J. Biol. Chem. (2006) [Pubmed]
  5. Effects of rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility. Honjo, M., Tanihara, H., Inatani, M., Kido, N., Sawamura, T., Yue, B.Y., Narumiya, S., Honda, Y. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  6. Shear stress-induced c-fos activation is mediated by Rho in a calcium-dependent manner. Shiu, Y.T., Li, S., Yuan, S., Wang, Y., Nguyen, P., Chien, S. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  7. Rho mediates the shear-enhancement of endothelial cell migration and traction force generation. Shiu, Y.T., Li, S., Marganski, W.A., Usami, S., Schwartz, M.A., Wang, Y.L., Dembo, M., Chien, S. Biophys. J. (2004) [Pubmed]
  8. Comparative analysis of precipitating antibodies in White Rock and Fayoumi hens injected with bovine serum albumin or crude mite extract with resulting effects on northern fowl mite, Ornithonyssus sylviarum (Acari: Macronyssidae) population densities. Burg, J.G., Collison, C.H., Mastro, A.M. Poult. Sci. (1988) [Pubmed]
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