Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

ClgVgp001 - orf1

Cryptophlebia leucotreta granulovirus

Jehle, J.A. et al., Burden, J.P. et al., Smith, I. et al., Crook, N.E. et al., Parola, A.D. et al.

Smith, Goodale,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ClgVgp001

Sequence comparison with the granulin genes of different granulosis viruses indicated a very close relationship between CIGV and CpGV of about 96% amino acid identity [1].
The 5' leader of the granulin gene contains a canonical late baculovirus promoter (ATAAG) and differs only in two nucleotide positions from the sequence of Cydia pomonella granulosis virus (CpGV) [1].

High impact information on ClgVgp001

Database searching revealed that part of a published DNA sequence from Cryptophlebia leucotreta granulovirus appears to encode the N-terminal region of EGT, and the relative genomic locations of the egt and granulin genes in that virus were compared with their positions in LoGV [2].
The region containing the granulin gene and an open reading frame immediately upstream of the granulin gene was sequenced [3].
Comprehensive physical map of the Cydia pomonella granulovirus genome and sequence analysis of the granulin gene region [3].
Homologous sequences to ORF909 are also present upstream of the granulin genes of other granulosis viruses (GVs) indicating that this ORF is common in GVs [1].
Granulin is a late-expressed gene that is only transcribed after viral genome replication, its presence thus strongly indicates that viral genome replication has occurred [4].

Biological context of ClgVgp001

The nucleotide sequence of a 2.2 kb genome region of the baculovirus Cryptophlebia leucotreta granulosis virus (CIGV) encompassing the granulin gene and a second open reading frame, designated ORF909, was determined [1].
Granulin mRNA was also detected in both the ovaries and testes, which may represent a putative mechanism by which reduced fecundity in sublethally affected hosts might be manifested [4].

Analytical, diagnostic and therapeutic context of ClgVgp001

The granulin gene region of Cryptophlebia leucotreta granulosis virus: sequence analysis and phylogenetic considerations [1].
The performance of the ELISA was satisfactory in terms of sensitivity, detecting as little as 0.53 ng/ml of EpapGV granulin in suspensions of purified virus OB [5].

References

The granulin gene region of Cryptophlebia leucotreta granulosis virus: sequence analysis and phylogenetic considerations. Jehle, J.A., Backhaus, H. J. Gen. Virol. (1994) [Pubmed]
Sequence and in vivo transcription of Lacanobia oleracea granulovirus egt. Smith, I., Goodale, C. J. Gen. Virol. (1998) [Pubmed]
Comprehensive physical map of the Cydia pomonella granulovirus genome and sequence analysis of the granulin gene region. Crook, N.E., James, J.D., Smith, I.R., Winstanley, D. J. Gen. Virol. (1997) [Pubmed]
Vertical transmission of sublethal granulovirus infection in the Indian meal moth, Plodia interpunctella. Burden, J.P., Griffiths, C.M., Cory, J.S., Smith, P., Sait, S.M. Mol. Ecol. (2002) [Pubmed]
An immunochemical method for quantitation of Epinotia aporema granulovirus (EpapGV). Parola, A.D., Sciocco-Cap, A., Glikmann, G., Romanowski, V. J. Virol. Methods (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.