High impact information on lin-10

• This result suggests that lin-10 may have a general but redundant role in development, functioning in diverse cell lineages to control cell fates [1].
• The location of lin-10 within this region was determined by identifying a transcript affected by three independent lin-10 mutations and by delimiting the minimal segment of DNA sufficient to rescue the lin-10 mutant phenotype in germ line transformation experiments [1].
• We demonstrate that the previous molecular identification of lin-10 was incorrect, and we identify a new gene corresponding to the lin-10 genetic locus. lin-10 encodes a protein with regions of similarity to mammalian X11/mint proteins, containing a phosphotyrosine-binding and two PDZ domains [2].
• Basolateral localization of the Caenorhabditis elegans epidermal growth factor receptor in epithelial cells by the PDZ protein LIN-10 [2].
• In addition to these gene products, the lin-2, lin-7, and lin-10 products are also implicated in this pathway [3].

Anatomical context of lin-10

• In brain, however, rat lin-10 is distributed only in the membrane fraction and enriched in the synaptic plasma membrane and postsynaptic density fractions [3].

Analytical, diagnostic and therapeutic context of lin-10

• Molecular cloning and characterization of rat lin-10 [3].
• As a first step in a molecular dissection of the pathway controlling the determination of vulval cell fates in Caenorhabditis elegans, we have analyzed the gene lin-10 [1].

References