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Gene Review

snt-1  -  Protein SNT-1

Caenorhabditis elegans

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High impact information on Synaptotagmin


Biological context of Synaptotagmin

  • Comparison of the genomic structures of the Syt genes makes clear the different phylogenies of the different subgroups [4].
  • I used TBLASTn to probe DNA sequence databases with a consensus peptide sequence corresponding to the most highly conserved region of the rodent synaptotagmin (Syt) gene family, which is within the C2B domain [4].


  1. Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin. Nonet, M.L., Grundahl, K., Meyer, B.J., Rand, J.B. Cell (1993) [Pubmed]
  2. Synaptic transmission deficits in Caenorhabditis elegans synaptobrevin mutants. Nonet, M.L., Saifee, O., Zhao, H., Rand, J.B., Wei, L. J. Neurosci. (1998) [Pubmed]
  3. Neural transmission. Synaptotagmin is just a calcium sensor. Kelly, R.B. Curr. Biol. (1995) [Pubmed]
  4. Genomic analysis of synaptotagmin genes. Craxton, M. Genomics (2001) [Pubmed]
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