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Gene Review

Syt1  -  Synaptotagmin 1

Drosophila melanogaster

Synonyms: CG3139, DSYT, DSYT2, DSypt, DSyt, ...
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Disease relevance of syt


High impact information on syt


Biological context of syt


Anatomical context of syt


Associations of syt with chemical compounds

  • The most extensively studied candidate for the Ca(2+)-sensing trigger is synaptotagmin I, whose Ca(2+)-dependent interactions with acidic phospholipids and syntaxin have largely been ascribed to its C(2)A domain, although the C(2)B domain also binds Ca(2+) (refs 7, 8) [5].
  • We mutated an essential aspartate of the Ca(2+)-binding site of the synaptotagmin I C(2)A domain and expressed it in Drosophila lacking synaptotagmin I [5].
  • To characterize Ca(2+)-mediated synaptic vesicle fusion, we analyzed Drosophila synaptotagmin I mutants deficient in specific interactions mediated by its two Ca(2+) binding C2 domains [13].
  • A tetracysteine motif that binds the membrane-permeable fluorescein derivative 4',5'-bis(1,3,2-dithioarsolan-2-yl)fluorescein (FlAsH) was engineered into synaptotagmin I (Syt I4C) [14].
  • We conclude that synaptotagmin interactions mediated by the C2 B polylysine motif are required to attain full synaptotagmin function in vivo [8].

Other interactions of syt


Analytical, diagnostic and therapeutic context of syt


  1. CREB-binding protein/p300 are transcriptional coactivators of p65. Gerritsen, M.E., Williams, A.J., Neish, A.S., Moore, S., Shi, Y., Collins, T. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. Synaptotagmin-like expression in the motor nerve terminals of crayfish. Cooper, R.L., Hampson, D.R., Atwood, H.L. Brain Res. (1995) [Pubmed]
  3. Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca(2+)-activated neurotransmitter release. Littleton, J.T., Stern, M., Schulze, K., Perin, M., Bellen, H.J. Cell (1993) [Pubmed]
  4. Synaptic transmission persists in synaptotagmin mutants of Drosophila. DiAntonio, A., Parfitt, K.D., Schwarz, T.L. Cell (1993) [Pubmed]
  5. Synaptotagmins I and IV promote transmitter release independently of Ca(2+) binding in the C(2)A domain. Robinson, I.M., Ranjan, R., Schwarz, T.L. Nature (2002) [Pubmed]
  6. Membrane fusion proteins are required for oskar mRNA localization in the Drosophila egg chamber. Ruden, D.M., Sollars, V., Wang, X., Mori, D., Alterman, M., Lu, X. Dev. Biol. (2000) [Pubmed]
  7. Immunocytochemical analysis of axonal outgrowth in synaptotagmin mutations. Littleton, J.T., Upton, L., Kania, A. J. Neurochem. (1995) [Pubmed]
  8. Mutations in the second C2 domain of synaptotagmin disrupt synaptic transmission at Drosophila neuromuscular junctions. Mackler, J.M., Reist, N.E. J. Comp. Neurol. (2001) [Pubmed]
  9. Synaptic function modulated by changes in the ratio of synaptotagmin I and IV. Littleton, J.T., Serano, T.L., Rubin, G.M., Ganetzky, B., Chapman, E.R. Nature (1999) [Pubmed]
  10. Syntaxin 1A interacts with multiple exocytic proteins to regulate neurotransmitter release in vivo. Wu, M.N., Fergestad, T., Lloyd, T.E., He, Y., Broadie, K., Bellen, H.J. Neuron (1999) [Pubmed]
  11. External Ca2+ dependency of synaptic transmission in drosophila synaptotagmin I mutants. Okamoto, T., Tamura, T., Suzuki, K., Kidokoro, Y. J. Neurophysiol. (2005) [Pubmed]
  12. The effects of 20-hydroxyecdysone on the differentiation in vitro of cells from the eye imaginal disc from Drosophila melanogaster. Li, C., Meinertzhagen, I.A. Invert. Neurosci. (1997) [Pubmed]
  13. Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release. Yoshihara, M., Littleton, J.T. Neuron (2002) [Pubmed]
  14. Transgenically encoded protein photoinactivation (FlAsH-FALI): acute inactivation of synaptotagmin I. Marek, K.W., Davis, G.W. Neuron (2002) [Pubmed]
  15. Identification and characterization of Drosophila genes for synaptic vesicle proteins. DiAntonio, A., Burgess, R.W., Chin, A.C., Deitcher, D.L., Scheller, R.H., Schwarz, T.L. J. Neurosci. (1993) [Pubmed]
  16. Postfusional control of quantal current shape. Pawlu, C., DiAntonio, A., Heckmann, M. Neuron (2004) [Pubmed]
  17. synaptotagmin mutants reveal essential functions for the C2B domain in Ca2+-triggered fusion and recycling of synaptic vesicles in vivo. Littleton, J.T., Bai, J., Vyas, B., Desai, R., Baltus, A.E., Garment, M.B., Carlson, S.D., Ganetzky, B., Chapman, E.R. J. Neurosci. (2001) [Pubmed]
  18. Direct observation demonstrates that Liprin-alpha is required for trafficking of synaptic vesicles. Miller, K.E., DeProto, J., Kaufmann, N., Patel, B.N., Duckworth, A., Van Vactor, D. Curr. Biol. (2005) [Pubmed]
  19. Expression of synaptotagmin in Drosophila reveals transport and localization of synaptic vesicles to the synapse. Littleton, J.T., Bellen, H.J., Perin, M.S. Development (1993) [Pubmed]
  20. Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats. Tetsuka, T., Uranishi, H., Imai, H., Ono, T., Sonta, S., Takahashi, N., Asamitsu, K., Okamoto, T. J. Biol. Chem. (2000) [Pubmed]
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