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SYT1  -  synaptotagmin I

Bos taurus

 
 
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Disease relevance of SYT1

  • The large cytoplasmic domain contains two C2 motifs, each similar to the Ca2+ and phospholipid binding domain of protein kinase C. To study the membrane binding and aggregating properties of these C2 domains, three recombinant fragments of rat synaptotagmin I were expressed in Escherichia coli and purified [1].
  • HTLV-I encoded Tax in association with NF-kappa B precursor p105 enhances nuclear localization of NF-kappa B p50 and p65 in transfected cells [2].
  • These results are consistent with the view that p65 is the precursor of gag gene-derived core proteins of BLV [3].
  • Furthermore, when expressed in the rat pheochromocytoma cell line PC12 bovine synaptotagmin I-DeltaC2B is largely absent from dense core granules and synaptic-like microvesicles [4].
 

High impact information on SYT1

 

Biological context of SYT1

 

Anatomical context of SYT1

 

Associations of SYT1 with chemical compounds

  • Synaptotagmin contains two divergent but conserved C2 domains that can act independently in calcium-triggered phospholipid binding [8].
  • Casein kinase II phosphorylation of many substrates is strongly stimulated by the addition of polylysine, but phosphorylation of synaptotagmin I by casein kinase II is not [9].
  • Synaptotagmin I is one of the major substrates in brain for casein kinase II, which phosphorylates synaptotagmin at a single threonine [9].
  • In recombinant proteins, removal of the lysine-rich sequence of synaptotagmin I makes its phosphorylation dependent on exogenous polylysine, suggesting that the lysine-rich sequence in synaptotagmin serves as an endogenous polylysine stimulation signal for casein kinase II [9].
  • The bovine homologue of p65, a calmodulin-binding protein located in the membranes of synaptic vesicles and endocrine secretory granules, has been studied by the use of monoclonal antibodies directed against this antigen and against dopamine beta-mono-oxygenase [10].
 

Other interactions of SYT1

 

Analytical, diagnostic and therapeutic context of SYT1

References

  1. Synergistic membrane interactions of the two C2 domains of synaptotagmin. Damer, C.K., Creutz, C.E. J. Biol. Chem. (1994) [Pubmed]
  2. HTLV-I encoded Tax in association with NF-kappa B precursor p105 enhances nuclear localization of NF-kappa B p50 and p65 in transfected cells. Watanabe, M., Muramatsu, M., Hirai, H., Suzuki, T., Fujisawa, J., Yoshida, M., Arai, K., Arai, N. Oncogene (1993) [Pubmed]
  3. Detection of a precursor-like protein of bovine leukaemia virus structural polypeptides in purified virions. Gupta, P., Ferrer, J.F. J. Gen. Virol. (1980) [Pubmed]
  4. Synaptotagmin I-DeltaC2B. A novel synaptotagmin isoform with a single C2 domain in the bovine adrenal medulla. Hewitt, E.W., Tao, J.X., Strasser, J.E., Cutler, D.F., Dean, G.E. Biochim. Biophys. Acta (2002) [Pubmed]
  5. A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion. Söllner, T., Bennett, M.K., Whiteheart, S.W., Scheller, R.H., Rothman, J.E. Cell (1993) [Pubmed]
  6. Binding of synaptotagmin to the alpha-latrotoxin receptor implicates both in synaptic vesicle exocytosis. Petrenko, A.G., Perin, M.S., Davletov, B.A., Ushkaryov, Y.A., Geppert, M., Südhof, T.C. Nature (1991) [Pubmed]
  7. Nuclear factor-kappa B interacts functionally with the platelet-derived growth factor B-chain shear-stress response element in vascular endothelial cells exposed to fluid shear stress. Khachigian, L.M., Resnick, N., Gimbrone, M.A., Collins, T. J. Clin. Invest. (1995) [Pubmed]
  8. Mechanism of calcium-independent synaptotagmin binding to target SNAREs. Rickman, C., Davletov, B. J. Biol. Chem. (2003) [Pubmed]
  9. Phosphorylation of synaptotagmin I by casein kinase II. Davletov, B., Sontag, J.M., Hata, Y., Petrenko, A.G., Fykse, E.M., Jahn, R., Südhof, T.C. J. Biol. Chem. (1993) [Pubmed]
  10. Glycosylation and transmembrane topography of bovine chromaffin granule p65. Tugal, H.B., van Leeuwen, F., Apps, D.K., Haywood, J., Phillips, J.H. Biochem. J. (1991) [Pubmed]
  11. Distinct roles of C2A and C2B domains of synaptotagmin in the regulation of exocytosis in adrenal chromaffin cells. Ohara-Imaizumi, M., Fukuda, M., Niinobe, M., Misonou, H., Ikeda, K., Murakami, T., Kawasaki, M., Mikoshiba, K., Kumakura, K. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  12. Interaction of synaptotagmin with the cytoplasmic domains of neurexins. Hata, Y., Davletov, B., Petrenko, A.G., Jahn, R., Südhof, T.C. Neuron (1993) [Pubmed]
  13. Synaptotagmin: a membrane constituent of neuropeptide-containing large dense-core vesicles. Walch-Solimena, C., Takei, K., Marek, K.L., Midyett, K., Südhof, T.C., De Camilli, P., Jahn, R. J. Neurosci. (1993) [Pubmed]
  14. Presence of syntaxin 1A in secretory granules of chromaffin cells and interaction with chromogranins A and B. Yoo, S.H., You, S.H., Huh, Y.H. FEBS Lett. (2005) [Pubmed]
  15. Characterization of vesicular membrane-bound alpha-SNAP and NSF in adrenal chromaffin cells. Banaschewski, C., Höhne-Zell, B., Ovtscharoff, W., Gratzl, M. Biochemistry (1998) [Pubmed]
  16. Interaction of Ash/Grb-2 via its SH3 domains with neuron-specific p150 and p65. Miura, K., Miki, H., Shimazaki, K., Kawai, N., Takenawa, T. Biochem. J. (1996) [Pubmed]
  17. SNAP-25 is present in a SNARE complex in adrenal chromaffin cells. Roth, D., Burgoyne, R.D. FEBS Lett. (1994) [Pubmed]
 
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