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Gene Review

syx-4  -  Protein SYX-4

Caenorhabditis elegans

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High impact information on syntaxin


Biological context of syntaxin


Anatomical context of syntaxin

  • Members of the syntaxin gene family are components of protein complexes which regulate vesicle docking and/or fusion during transport of cargo through the secretory pathway of eukaryotic cells [10].
  • Members of the syntaxin family of integral membrane proteins have recently been implicated as vesicle receptors on target membranes, coresponsible for the specificity of intracellular membrane traffic [11].
  • Epitope-tagged syntaxin-16A and syntaxin-16B were found to colocalize with the Golgi marker beta-COP, while syntaxin-16C was found in the cytosol [11].

Associations of syntaxin with chemical compounds


Analytical, diagnostic and therapeutic context of syntaxin

  • Immuno-precipitation and immunoblotting with the monoclonal antibody HPC-1 and a polyclonal antibody raised against a peptide corresponding to the unique C-terminal 35 residues of syntaxin 1C failed to detect syntaxin 1C at the protein level in extracts of muscle, fat or brain [9].


  1. Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin. Hata, Y., Slaughter, C.A., Südhof, T.C. Nature (1993) [Pubmed]
  2. Synaptic transmission deficits in Caenorhabditis elegans synaptobrevin mutants. Nonet, M.L., Saifee, O., Zhao, H., Rand, J.B., Wei, L. J. Neurosci. (1998) [Pubmed]
  3. SNARE complex zero layer residues are not critical for N-ethylmaleimide-sensitive factor-mediated disassembly. Lauer, J.M., Dalal, S., Marz, K.E., Nonet, M.L., Hanson, P.I. J. Biol. Chem. (2006) [Pubmed]
  4. UNC-13 interaction with syntaxin is required for synaptic transmission. Madison, J.M., Nurrish, S., Kaplan, J.M. Curr. Biol. (2005) [Pubmed]
  5. Depletion of syntaxins in the early Caenorhabditis elegans embryo reveals a role for membrane fusion events in cytokinesis. Jantsch-Plunger, V., Glotzer, M. Curr. Biol. (1999) [Pubmed]
  6. Tomosyn Inhibits Synaptic Vesicle Priming in Caenorhabditis elegans. Gracheva, E.O., Burdina, A.O., Holgado, A.M., Berthelot-Grosjean, M., Ackley, B.D., Hadwiger, G., Nonet, M.L., Weimer, R.M., Richmond, J.E. PLoS Biol. (2006) [Pubmed]
  7. Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin. Betz, A., Okamoto, M., Benseler, F., Brose, N. J. Biol. Chem. (1997) [Pubmed]
  8. A novel isoform of syntaxin-binding protein homologous to yeast Sec1 expressed ubiquitously in mammalian cells. Katagiri, H., Terasaki, J., Murata, T., Ishihara, H., Ogihara, T., Inukai, K., Fukushima, Y., Anai, M., Kikuchi, M., Miyazaki, J. J. Biol. Chem. (1995) [Pubmed]
  9. Novel isoform of syntaxin 1 is expressed in mammalian cells. Jagadish, M.N., Tellam, J.T., Macaulay, S.L., Gough, K.H., James, D.E., Ward, C.W. Biochem. J. (1997) [Pubmed]
  10. Mammalian Sly1 regulates syntaxin 5 function in endoplasmic reticulum to Golgi transport. Dascher, C., Balch, W.E. J. Biol. Chem. (1996) [Pubmed]
  11. Syntaxin-16, a putative Golgi t-SNARE. Simonsen, A., Bremnes, B., Rønning, E., Aasland, R., Stenmark, H. Eur. J. Cell Biol. (1998) [Pubmed]
  12. Volatile anesthetics bind rat synaptic snare proteins. Nagele, P., Mendel, J.B., Placzek, W.J., Scott, B.A., D'Avignon, D.A., Crowder, C.M. Anesthesiology (2005) [Pubmed]
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