Gene Review:
Por - P450 (cytochrome) oxidoreductase
Mus musculus
Synonyms:
4933424M13Rik, CPR, CYPOR, NADH cytochrome P450 oxydoreductase, NADPH--cytochrome P450 reductase, ...
- Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype. Weng, Y., DiRusso, C.C., Reilly, A.A., Black, P.N., Ding, X. J. Biol. Chem. (2005)
- Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase. Henderson, C.J., Otto, D.M., Carrie, D., Magnuson, M.A., McLaren, A.W., Rosewell, I., Wolf, C.R. J. Biol. Chem. (2003)
- Hypoxia targeted gene therapy to increase the efficacy of tirapazamine as an adjuvant to radiotherapy: reversing tumor radioresistance and effecting cure. Cowen, R.L., Williams, K.J., Chinje, E.C., Jaffar, M., Sheppard, F.C., Telfer, B.A., Wind, N.S., Stratford, I.J. Cancer Res. (2004)
- Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain. Qu, W., Bradbury, J.A., Tsao, C.C., Maronpot, R., Harry, G.J., Parker, C.E., Davis, L.S., Breyer, M.D., Waalkes, M.P., Falck, J.R., Chen, J., Rosenberg, R.L., Zeldin, D.C. J. Biol. Chem. (2001)
- Presence of NADPH-cytochrome P450 reductase in central catecholaminergic neurones. Haglund, L., Köhler, C., Haaparanta, T., Goldstein, M., Gustafsson, J.A. Nature (1984)
- N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen. Dahlin, D.C., Miwa, G.T., Lu, A.Y., Nelson, S.D. Proc. Natl. Acad. Sci. U.S.A. (1984)
- Purification and characterization of cytochrome P-450 induced by benz(a)anthracene in mouse skin microsomes. Ichikawa, T., Hayashi, S., Noshiro, M., Takada, K., Okuda, K. Cancer Res. (1989)
- Benzo(a)pyrene metabolism by murine spleen microsomes. Kawabata, T.T., White, K.L. Cancer Res. (1989)
- Cloning and constitutive expression of structural genes encoding gonococcal porin protein in Escherichia coli and attenuated Salmonella typhimurium vaccine strains. Elkins, C., Carbonetti, N.H., Coímbre, A.J., Thomas, C.E., Sparling, P.F. Gene (1994)
- In vivo mechanisms of tissue-selective drug toxicity: effects of liver-specific knockout of the NADPH-cytochrome P450 reductase gene on acetaminophen toxicity in kidney, lung, and nasal mucosa. Gu, J., Cui, H., Behr, M., Zhang, L., Zhang, Q.Y., Yang, W., Hinson, J.A., Ding, X. Mol. Pharmacol. (2005)
- P450 (cytochrome) oxidoreductase (Por) maps to mouse chromosome 5, not chromosome 6. Spearow, J.L. Mamm. Genome (1995)
- Association of multiple developmental defects and embryonic lethality with loss of microsomal NADPH-cytochrome P450 oxidoreductase. Shen, A.L., O'Leary, K.A., Kasper, C.B. J. Biol. Chem. (2002)
- Conditional knockout of the mouse NADPH-cytochrome p450 reductase gene. Wu, L., Gu, J., Weng, Y., Kluetzman, K., Swiatek, P., Behr, M., Zhang, Q.Y., Zhuo, X., Xie, Q., Ding, X. Genesis (2003)
- Two novel sites of expression of NADPH cytochrome P450 reductase during murine embryogenesis: limb mesenchyme and developing olfactory neuroepithelia. Keeney, D.S., Waterman, M.R. Dev. Dyn. (1999)
- Changes in hepatic xenobiotic-metabolising enzymes in mouse liver following infection with Leishmania donovani. Coombs, G.H., Wolf, C.R., Morrison, V.M., Craft, J.A. Mol. Biochem. Parasitol. (1990)
- Targeted integration of DNA using mutant lox sites in embryonic stem cells. Araki, K., Araki, M., Yamamura, K. Nucleic Acids Res. (1997)
- A Mouse Model with Liver-Specific Deletion and Global Suppression of the NADPH-Cytochrome P450 Reductase Gene: Characterization and Utility for in Vivo Studies of Cyclophosphamide Disposition. Gu, J., Chen, C.S., Wei, Y., Fang, C., Xie, F., Kannan, K., Yang, W., Waxman, D.J., Ding, X. J. Pharmacol. Exp. Ther. (2007)
- Nitric oxide synthase is a cytochrome P-450 type hemoprotein. White, K.A., Marletta, M.A. Biochemistry (1992)
- Opposing mechanisms of NADPH-cytochrome P450 oxidoreductase regulation by peroxisome proliferators. Fan, L.Q., Coley, J., Miller, R.T., Cattley, R.C., Corton, J.C. Biochem. Pharmacol. (2003)
- Mouse cytochrome P450 (Cyp3a11): predominant expression in liver and capacity to activate aflatoxin B1. Yanagimoto, T., Itoh, S., Sawada, M., Kamataki, T. Arch. Biochem. Biophys. (1997)
- Molecular cloning and functional expression of a mouse cytochrome P-450 (Cyp3a-13): examination of Cyp3a-13 enzyme to activate aflatoxin B1 (AFB1). Yanagimoto, T., Itoh, S., Sawada, M., Hashimoto, H., Kamataki, T. Biochim. Biophys. Acta (1994)
- NADPH-cytochrome P-450 reductase, cytochrome P-450 2C11 and P-450 1A1, and the aryl hydrocarbon receptor in livers of rats fed methyl-folate-deficient diets. Zhang, J., Henning, S.M., Heber, D., Choi, J., Wang, Y., Swendseid, M.E., Go, V.L. Nutrition and cancer. (1997)
- Viral delivery of P450 reductase recapitulates the ability of constitutive overexpression of reductase enzymes to potentiate the activity of mitomycin C in human breast cancer xenografts. Cowen, R.L., Patterson, A.V., Telfer, B.A., Airley, R.E., Hobbs, S., Phillips, R.M., Jaffar, M., Stratford, I.J., Williams, K.J. Mol. Cancer Ther. (2003)
- Hepatic mitochondrial coumarin 7-hydroxylase: comparison with the microsomal enzyme. Honkakoski, P., Kojo, A., Raunio, H., Pasanen, M., Juvonen, R., Lang, M.A. Arch. Biochem. Biophys. (1988)
- Selenium and drug metabolism--II. Independence of glutathione peroxidase and reversibility of hepatic enzyme modulations in deficient mice. Reiter, R., Wendel, A. Biochem. Pharmacol. (1984)
- Purification and partial characterization of NADPH-cytochrome c reductase from Petunia hybrida flowers. Menting, J.G., Cornish, E., Scopes, R.K. Plant Physiol. (1994)
- Characterization of the cytochrome P-450 monooxygenase system in nonciliated bronchiolar epithelial (Clara) cells isolated from mouse lung. Chichester, C.H., Philpot, R.M., Weir, A.J., Buckpitt, A.R., Plopper, C.G. Am. J. Respir. Cell Mol. Biol. (1991)
- Alterations in expression of CYP1A1 and NADPH-cytochrome P450 reductase during lung tumor development in SWR/J mice. Forkert, P.G., Lord, J.A., Parkinson, A. Carcinogenesis (1996)
- Catalytic and immunochemical properties of NADPH-cytochrome P450 reductase from fungus Rhizopus nigricans. Makovec, T., Breskvar, K. J. Steroid Biochem. Mol. Biol. (2002)