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Gene Review

K07C5.2  -  Protein K07C5.2

Caenorhabditis elegans

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High impact information on reductase


Biological context of reductase


Anatomical context of reductase


Associations of reductase with chemical compounds


Other interactions of reductase

  • The stress-related gene, SAM-22, phospholipase D and 12-oxophytodienoate reductase were also induced at the early time-points [16].
  • Thioredoxin (TRX) is generally a 12-kDa protein-disulfide reductase [17].
  • Loss of emb-8, a previously uncharacterized polarity gene, causes mislocalization of PAR-3 and PAR-2 that molecularly mark the anterior and posterior cortices. emb-8 encodes NADPH-cytochrome P450 reductase, a protein supplying electrons to cytochrome P450-family enzymes, some of which catalyze fatty acid modifications [18].

Analytical, diagnostic and therapeutic context of reductase

  • Immunoblotting of A. suum larval stages and adult tissues with antisera that cross-reacted with each of the spots separated on two-dimensional gels suggested that the reductase was only found in adult muscle [4].
  • Enzymes in this system, such as NADH-rhodoquinone reductase (complex I) and rhodoquinol-fumarate reductase (complex II), form promising targets for chemotherapy [7].


  1. Components of sterol biosynthesis assembled on the oxygen-avid hemoglobin of Ascaris. Sherman, D.R., Guinn, B., Perdok, M.M., Goldberg, D.E. Science (1992) [Pubmed]
  2. CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans. Felkai, S., Ewbank, J.J., Lemieux, J., Labbé, J.C., Brown, G.G., Hekimi, S. EMBO J. (1999) [Pubmed]
  3. Purification and characterization of electron-transfer flavoprotein: rhodoquinone oxidoreductase from anaerobic mitochondria of the adult parasitic nematode, Ascaris suum. Ma, Y.C., Funk, M., Dunham, W.R., Komuniecki, R. J. Biol. Chem. (1993) [Pubmed]
  4. Characterization of cDNA clones for the 2-methyl branched-chain enoyl-CoA reductase. An enzyme involved in branched-chain fatty acid synthesis in anaerobic mitochondria of the parasitic nematode Ascaris suum. Duran, E., Komuniecki, R.W., Komuniecki, P.R., Wheelock, M.J., Klingbeil, M.M., Ma, Y.C., Johnson, K.R. J. Biol. Chem. (1993) [Pubmed]
  5. Metabolism of plant sterols by nematodes. Chitwood, D.J., Lusby, W.R. Lipids (1991) [Pubmed]
  6. Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans. Miyadera, H., Amino, H., Hiraishi, A., Taka, H., Murayama, K., Miyoshi, H., Sakamoto, K., Ishii, N., Hekimi, S., Kita, K. J. Biol. Chem. (2001) [Pubmed]
  7. Parasite mitochondria as drug target: diversity and dynamic changes during the life cycle. Kita, K., Nihei, C., Tomitsuka, E. Current medicinal chemistry. (2003) [Pubmed]
  8. Short-chain dehydrogenase/reductase (SDR) relationships: a large family with eight clusters common to human, animal, and plant genomes. Kallberg, Y., Oppermann, U., Jörnvall, H., Persson, B. Protein Sci. (2002) [Pubmed]
  9. Gene linkage and steady state RNAs suggest trans-splicing may be associated with a polycistronic transcript in Schistosoma mansoni. Davis, R.E., Hodgson, S. Mol. Biochem. Parasitol. (1997) [Pubmed]
  10. Some properties of the sulphoxidases and sulphoxide reductases of the cestode Moniezia expansa, the nematode Ascaris suum and mouse liver. Douch, P.G., Buchanan, L.L. Xenobiotica (1979) [Pubmed]
  11. Thienylimidazo[2,1-b]thiazoles as inhibitors of mitochondrial NADH dehydrogenase. Andreani, A., Rambaldi, M., Leoni, A., Locatelli, A., Ghelli, A., Ratta, M., Benelli, B., Degli Esposti, M. J. Med. Chem. (1995) [Pubmed]
  12. Inhibition of C28 and C29 phytosterol metabolism by N,N-dimethyldodecanamine in the nematode Caenorhabditis elegans. Lozano, R., Lusby, W.R., Chitwood, D.J., Thompson, M.J., Svoboda, J.A. Lipids (1985) [Pubmed]
  13. Novel nuclear methylation of sterols by the nematode Caenorhabditis elegans. Chitwood, D.J., Lusby, W.R., Lozano, R., Thompson, M.J., Svoboda, J.A. Steroids (1983) [Pubmed]
  14. 17beta-hydroxysteroid dehydrogenase type 7--an ancient 3-ketosteroid reductase of cholesterogenesis. Breitling, R., Krazeisen, A., Möller, G., Adamski, J. Mol. Cell. Endocrinol. (2001) [Pubmed]
  15. Peroxide-supported in-vitro cytochrome P450 activities in Haemonchus contortus. Kotze, A.C. Int. J. Parasitol. (1999) [Pubmed]
  16. Timecourse microarray analyses reveal global changes in gene expression of susceptible Glycine max (soybean) roots during infection by Heterodera glycines (soybean cyst nematode). Alkharouf, N.W., Klink, V.P., Chouikha, I.B., Beard, H.S., Macdonald, M.H., Meyer, S., Knap, H.T., Khan, R., Matthews, B.F. Planta (2006) [Pubmed]
  17. An evolutionarily conserved 16-kDa thioredoxin-related protein is an antioxidant which regulates the NF-kappaB signaling pathway. Wang, X.W., Liou, Y.C., Ho, B., Ding, J.L. Free Radic. Biol. Med. (2007) [Pubmed]
  18. Involvement of fatty acid pathways and cortical interaction of the pronuclear complex in Caenorhabditis elegans embryonic polarity. Rappleye, C.A., Tagawa, A., Le Bot, N., Ahringer, J., Aroian, R.V. BMC Dev. Biol. (2003) [Pubmed]
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