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Gene Review

Por  -  P450 (cytochrome) oxidoreductase

Rattus norvegicus

Synonyms: CPR, NADPH--cytochrome P450 reductase, P450R
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Disease relevance of Por


High impact information on Por


Chemical compound and disease context of Por


Biological context of Por

  • These results indicated that a functional electron-transport chain consisting of rat NADPH-cytochrome P-450 reductase and rat cytochrome P-450MC was constructed in S. cerevisiae cells [13].
  • Similarities in amino acid sequence and in functional domain arrangement with other key flavoproteins, including nitric oxide synthase, make CPR an excellent prototype for studies of interactions between two flavin cofactors [14].
  • On the other hand, Lys(149) is close to a cluster of acidic amino acids near the FMN binding site of CPR [15].
  • Alkylation of cytochrome P-450c with BrNAP markedly stimulated (approximately 30-fold) its rate of anaerobic reduction by NADPH-cytochrome P-450 reductase, as determined by stopped flow spectroscopy [16].
  • The gene coding for the Candida tropicalis NADPH-cytochrome P-450 oxidoreductase (CPR, NADPH: ferricytochrome oxidoreductase, EC was isolated by immunoscreening of a C. tropicalis lambda gt11 expression library and colony hybridization of a C. tropicalis genomic library [17].

Anatomical context of Por


Associations of Por with chemical compounds


Physical interactions of Por


Enzymatic interactions of Por


Regulatory relationships of Por


Other interactions of Por


Analytical, diagnostic and therapeutic context of Por


  1. Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN- and FAD-containing enzymes. Wang, M., Roberts, D.L., Paschke, R., Shea, T.M., Masters, B.S., Kim, J.J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. Thyroid regulation of NADPH:cytochrome P450 oxidoreductase: identification of a thyroid-responsive element in the 5'-flank of the oxidoreductase gene. O'Leary, K.A., Li, H.C., Ram, P.A., McQuiddy, P., Waxman, D.J., Kasper, C.B. Mol. Pharmacol. (1997) [Pubmed]
  3. Synergistic interactions between NADPH-cytochrome P-450 reductase, paraquat, and iron in the generation of active oxygen radicals. Clejan, L., Cederbaum, A.I. Biochem. Pharmacol. (1989) [Pubmed]
  4. Evaluation of thyroid hormone effects on liver P450 reductase translation. Apletalina, E.V., Li, H.C., Waxman, D.J. Arch. Biochem. Biophys. (2003) [Pubmed]
  5. Rebamipide ameliorates hepatic dysfunction induced by ischemia/reperfusion in rats. Lee, S.M., Kim, K.H. Eur. J. Pharmacol. (1995) [Pubmed]
  6. Presence of NADPH-cytochrome P450 reductase in central catecholaminergic neurones. Haglund, L., Köhler, C., Haaparanta, T., Goldstein, M., Gustafsson, J.A. Nature (1984) [Pubmed]
  7. Hepatic response to right ventricular pressure overload. Gieling, R.G., Ruijter, J.M., Maas, A.A., Van Den Bergh Weerman, M.A., Dingemans, K.P., ten Kate, F.J., Lekanne dit Deprez, R.H., Moorman, A.F., Lamers, W.H. Gastroenterology (2004) [Pubmed]
  8. Oxidative metabolism of foreign compounds in rat small intestine: cellular localization and dependence on dietary iron. Hoensch, H., Woo, C.H., Raffin, S.B., Schmid, R. Gastroenterology (1976) [Pubmed]
  9. Evolutionarily divergent electron donor proteins interact with P450MT2 through the same helical domain but different contact points. Anandatheerthavarada, H.K., Amuthan, G., Biswas, G., Robin, M.A., Murali, R., Waterman, M.R., Avadhani, N.G. EMBO J. (2001) [Pubmed]
  10. Relationship between cytochrome P450 catalytic cycling and stability: fast degradation of ethanol-inducible cytochrome P450 2E1 (CYP2E1) in hepatoma cells is abolished by inactivation of its electron donor NADPH-cytochrome P450 reductase. Zhukov, A., Ingelman-Sundberg, M. Biochem. J. (1999) [Pubmed]
  11. Liver microsomal parameters related to oxidative stress and antioxidant systems in hyperthyroid rats subjected to acute lindane treatment. Simon Giavarotti, K.A., Rodrigues, L., Rodrigues, T., Junqueira, V.B., Videla, L.A. Free Radic. Res. (1998) [Pubmed]
  12. Preparation of homogeneous NADPH-cytochrome P-450 reductase from rat hepatoma. Fennell, P.M., Strobel, H.W. Biochim. Biophys. Acta (1982) [Pubmed]
  13. Expression of rat NADPH-cytochrome P-450 reductase cDNA in Saccharomyces cerevisiae. Murakami, H., Yabusaki, Y., Ohkawa, H. DNA (1986) [Pubmed]
  14. Crystallization and preliminary x-ray studies of NADPH-cytochrome P450 reductase. Djordjevic, S., Roberts, D.L., Wang, M., Shea, T., Camitta, M.G., Masters, B.S., Kim, J.J. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  15. Involvement of NADPH in the interaction between heme oxygenase-1 and cytochrome P450 reductase. Higashimoto, Y., Sakamoto, H., Hayashi, S., Sugishima, M., Fukuyama, K., Palmer, G., Noguchi, M. J. Biol. Chem. (2005) [Pubmed]
  16. Mechanism of inactivation of rat liver microsomal cytochrome P-450c by 2-bromo-4'-nitroacetophenone. Parkinson, A., Thomas, P.E., Ryan, D.E., Gorsky, L.D., Shively, J.E., Sayer, J.M., Jerina, D.M., Levin, W. J. Biol. Chem. (1986) [Pubmed]
  17. Isolation and characterization of the alkane-inducible NADPH-cytochrome P-450 oxidoreductase gene from Candida tropicalis. Identification of invariant residues within similar amino acid sequences of divergent flavoproteins. Sutter, T.R., Sanglard, D., Loper, J.C., Sangard, D. J. Biol. Chem. (1990) [Pubmed]
  18. Presence of NADPH-cytochrome P-450 reductase in rat liver Golgi membranes. Evidence obtained by immunoadsorption method. Ito, A., Palade, G.E. J. Cell Biol. (1978) [Pubmed]
  19. Cytochrome P-450 and NADPH-cytochrome P-450 reductase are degraded in the autolysosomes in rat liver. Masaki, R., Yamamoto, A., Tashiro, Y. J. Cell Biol. (1987) [Pubmed]
  20. Participation of cytochrome P-450 in reductive metabolism of 1-nitropyrene by rat liver microsomes. Saito, K., Kamataki, T., Kato, R. Cancer Res. (1984) [Pubmed]
  21. Immunohistochemical localization of cytochrome P-450 and reduced nicotinamide adenine dinucleotide phosphate:cytochrome P-450 reductase in the rat ventral prostate. Haaparanta, T., Norgård, M., Haglund, L., Glaumann, H., Gustafsson, J.A. Cancer Res. (1985) [Pubmed]
  22. Purified NADPH cytochrome P-450 reductase. Interaction with hepatic microsomes and phospholipid vesicles. Gum, J.R., Strobel, H.W. J. Biol. Chem. (1979) [Pubmed]
  23. Inhibitory effect of alpha-tocopherol on benzo(a)pyrene-induced CYPA1 activity in rat liver. Sidorova, Y.A., Grishanova, A.Y. Bull. Exp. Biol. Med. (2005) [Pubmed]
  24. NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals. Bachur, N.R., Gordon, S.L., Gee, M.V., Kon, H. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  25. An enzymatically active chimeric protein containing the hydrophilic form of NADPH-cytochrome P450 reductase fused to the membrane-binding domain of cytochrome b5. Gilep, A.A., Guryev, O.L., Usanov, S.A., Estabrook, R.W. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  26. The roles of cytochrome b5 in reconstituted monooxygenase systems containing various forms of hepatic microsomal cytochrome P-450. Imai, Y. J. Biochem. (1981) [Pubmed]
  27. Effects of superoxide dismutase and catalase during reduction of adrenochrome by DT-diaphorase and NADPH-cytochrome P450 reductase. Baez, S., Segura-Aguilar, J. Biochem. Mol. Med. (1995) [Pubmed]
  28. Vanadate-dependent NAD(P)H oxidation by microsomal enzymes. Reif, D.W., Coulombe, R.A., Aust, S.D. Arch. Biochem. Biophys. (1989) [Pubmed]
  29. Superoxide dismutase and catalase enhance autoxidation during one-electron reduction of aminochrome by NADPH-cytochrome P-450 reductase. Baez, S., Linderson, Y., Segura-Aguilar, J. Biochem. Mol. Med. (1995) [Pubmed]
  30. The effect of the tert-butylquinone metabolite of butylated hydroxyanisole on cytochrome P-450 monooxygenase activity. Cummings, S.W., Curtis, B.B., Peterson, J.A., Prough, R.A. Xenobiotica (1990) [Pubmed]
  31. Photolysis products of 2,4,5,2',4',5'-hexabromobiphenyl: hepatic microsomal enzyme induction and toxicity in Sprague-Dawley rats. Millis, C.D., Mills, R., Sleight, S.D., Aust, S.D. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1985) [Pubmed]
  32. Dicoumarol-sensitive glucuronidation of benzo(a)pyrene metabolites in rat liver microsomes. Segura-Aguilar, J.E., Barreiro, V., Lind, C. Arch. Biochem. Biophys. (1986) [Pubmed]
  33. Identification of outer mitochondrial membrane cytochrome b5 as a modulator for androgen synthesis in Leydig cells. Ogishima, T., Kinoshita, J.Y., Mitani, F., Suematsu, M., Ito, A. J. Biol. Chem. (2003) [Pubmed]
  34. Kainic acid induction of heme oxygenase in vivo and in vitro. Matsuoka, Y., Kitamura, Y., Okazaki, M., Kakimura, J., Tooyama, I., Kimura, H., Taniguchi, T. Neuroscience (1998) [Pubmed]
  35. Differential regulation of heme oxygenase isozymes by Sn- and Zn-protoporphyrins: possible relevance to suppression of hyperbilirubinemia. Maines, M.D., Trakshel, G.M. Biochim. Biophys. Acta (1992) [Pubmed]
  36. Trace detection of hydroxyl radicals during the redox cycling of low concentrations of diaziquone: a new approach. Li, B., Blough, N.V., Gutierrez, P.L. Free Radic. Biol. Med. (2000) [Pubmed]
  37. Effects of norepinephrine and angiotensin II on the determinants of glomerular ultrafiltration and proximal tubule fluid reabsorption in the rat. Myers, B.D., Deen, W.M., Brenner, B.M. Circ. Res. (1975) [Pubmed]
  38. Induction of microsomal NADPH-cytochrome P-450 reductase and cytochrome P-450IVA1 (P-450LA omega) by dehydroepiandrosterone in rats: a possible peroxisomal proliferator. Wu, H.Q., Masset-Brown, J., Tweedie, D.J., Milewich, L., Frenkel, R.A., Martin-Wixtrom, C., Estabrook, R.W., Prough, R.A. Cancer Res. (1989) [Pubmed]
  39. Purified liver microsomal NADPH-cytochrome P-450 reductase. Spectral characterization of oxidation-reduction states. Vermilion, J.L., Coon, M.J. J. Biol. Chem. (1978) [Pubmed]
  40. Rotation of cytochrome P-450. Complex formation of cytochrome P-450 with NADPH-cytochrome P-450 reductase in liposomes demonstrated by combining protein rotation with antibody-induced cross-linking. Gut, J., Richter, C., Cherry, R.J., Winterhalter, K.H., Kawato, S. J. Biol. Chem. (1983) [Pubmed]
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